McLoughlin S - Search Results

1

Bcl-XL represents a druggable molecular vulnerability during aurora B inhibitor-mediated polyploidization.

Shah OJ, Lin X, Li L, Huang X, Li J, Anderson MG, Tang H, Rodriguez LE, Warder SE, McLoughlin S, Chen J, Palma J, Glaser KB, Donawho CK, Fesik SW, Shen Y. Shah OJ, et al. Among authors: mcloughlin s. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12634-9. doi: 10.1073/pnas.0913615107. Epub 2010 Jun 28. Proc Natl Acad Sci U S A. 2010. PMID: 20616035 Free PMC article.

2

Discovery, identification, and characterization of candidate pharmacodynamic markers of methionine aminopeptidase-2 inhibition.

Warder SE, Tucker LA, McLoughlin SM, Strelitzer TJ, Meuth JL, Zhang Q, Sheppard GS, Richardson PL, Lesniewski R, Davidsen SK, Bell RL, Rogers JC, Wang J. Warder SE, et al. Among authors: mcloughlin sm. J Proteome Res. 2008 Nov;7(11):4807-20. doi: 10.1021/pr800388p. Epub 2008 Oct 2. J Proteome Res. 2008. PMID: 18828628

3

Target Identification of Compounds from a Cell Viability Phenotypic Screen Using a Bead/Lysate-Based Affinity Capture Platform.

Tang H, Duggan S, Richardson PL, Marin V, Warder SE, McLoughlin SM. Tang H, et al. Among authors: mcloughlin sm. J Biomol Screen. 2016 Feb;21(2):201-11. doi: 10.1177/1087057115622431. Epub 2015 Dec 16. J Biomol Screen. 2016. PMID: 26676096

4

Emerging Approaches for the Identification of Protein Targets of Small Molecules - A Practitioners' Perspective.

Comess KM, McLoughlin SM, Oyer JA, Richardson PL, Stöckmann H, Vasudevan A, Warder SE. Comess KM, et al. J Med Chem. 2018 Oct 11;61(19):8504-8535. doi: 10.1021/acs.jmedchem.7b01921. Epub 2018 Jun 6. J Med Chem. 2018. PMID: 29718665

5

Transmembrane TNF-dependent uptake of anti-TNF antibodies.

Deora A, Hegde S, Lee J, Choi CH, Chang Q, Lee C, Eaton L, Tang H, Wang D, Lee D, Michalak M, Tomlinson M, Tao Q, Gaur N, Harvey B, McLoughlin S, Labkovsky B, Ghayur T. Deora A, et al. Among authors: mcloughlin s. MAbs. 2017 May/Jun;9(4):680-695. doi: 10.1080/19420862.2017.1304869. Epub 2017 Mar 21. MAbs. 2017. PMID: 28323513 Free PMC article.

6

Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors.

Wilsbacher JL, Cheng M, Cheng D, Trammell SAJ, Shi Y, Guo J, Koeniger SL, Kovar PJ, He Y, Selvaraju S, Heyman HR, Sorensen BK, Clark RF, Hansen TM, Longenecker KL, Raich D, Korepanova AV, Cepa S, Towne DL, Abraham VC, Tang H, Richardson PL, McLoughlin SM, Badagnani I, Curtin ML, Michaelides MR, Maag D, Buchanan FG, Chiang GG, Gao W, Rosenberg SH, Brenner C, Tse C. Wilsbacher JL, et al. Among authors: mcloughlin sm. Mol Cancer Ther. 2017 Jul;16(7):1236-1245. doi: 10.1158/1535-7163.MCT-16-0819. Epub 2017 May 3. Mol Cancer Ther. 2017. PMID: 28468779

7

Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase.

Yin J, Straight PD, McLoughlin SM, Zhou Z, Lin AJ, Golan DE, Kelleher NL, Kolter R, Walsh CT. Yin J, et al. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15815-20. doi: 10.1073/pnas.0507705102. Epub 2005 Oct 19. Proc Natl Acad Sci U S A. 2005. PMID: 16236721 Free PMC article.

8

Role of the active site cysteine of DpgA, a bacterial type III polyketide synthase.

Tseng CC, McLoughlin SM, Kelleher NL, Walsh CT. Tseng CC, et al. Biochemistry. 2004 Feb 3;43(4):970-80. doi: 10.1021/bi035714b. Biochemistry. 2004. PMID: 14744141

9

Elucidating the substrate specificity and condensation domain activity of FkbP, the FK520 pipecolate-incorporating enzyme.

Gatto GJ Jr, McLoughlin SM, Kelleher NL, Walsh CT. Gatto GJ Jr, et al. Biochemistry. 2005 Apr 26;44(16):5993-6002. doi: 10.1021/bi050230w. Biochemistry. 2005. PMID: 15835888

10

Kinetic and regiospecific interrogation of covalent intermediates in the nonribosomal peptide synthesis of yersiniabactin.

McLoughlin SM, Kelleher NL. McLoughlin SM, et al. J Am Chem Soc. 2004 Oct 20;126(41):13265-75. doi: 10.1021/ja0470867. J Am Chem Soc. 2004. PMID: 15479080 Free PMC article.

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