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Role of IL-1beta in type 2 diabetes.
Dinarello CA, Donath MY, Mandrup-Poulsen T. Dinarello CA, et al. Among authors: donath my. Curr Opin Endocrinol Diabetes Obes. 2010 Aug;17(4):314-21. doi: 10.1097/MED.0b013e32833bf6dc. Curr Opin Endocrinol Diabetes Obes. 2010. PMID: 20588114 Review.
Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.
Maedler K, Størling J, Sturis J, Zuellig RA, Spinas GA, Arkhammar PO, Mandrup-Poulsen T, Donath MY. Maedler K, et al. Among authors: donath my. Diabetes. 2004 Jul;53(7):1706-13. doi: 10.2337/diabetes.53.7.1706. Diabetes. 2004. PMID: 15220194
The Fas pathway is involved in pancreatic beta cell secretory function.
Schumann DM, Maedler K, Franklin I, Konrad D, Størling J, Böni-Schnetzler M, Gjinovci A, Kurrer MO, Gauthier BR, Bosco D, Andres A, Berney T, Greter M, Becher B, Chervonsky AV, Halban PA, Mandrup-Poulsen T, Wollheim CB, Donath MY. Schumann DM, et al. Among authors: donath my. Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2861-6. doi: 10.1073/pnas.0611487104. Epub 2007 Feb 13. Proc Natl Acad Sci U S A. 2007. PMID: 17299038 Free PMC article.
Interleukin-1-receptor antagonist in type 2 diabetes mellitus.
Larsen CM, Faulenbach M, Vaag A, Vølund A, Ehses JA, Seifert B, Mandrup-Poulsen T, Donath MY. Larsen CM, et al. Among authors: donath my. N Engl J Med. 2007 Apr 12;356(15):1517-26. doi: 10.1056/NEJMoa065213. N Engl J Med. 2007. PMID: 17429083 Free article. Clinical Trial.
Proliferation of sorted human and rat beta cells.
Parnaud G, Bosco D, Berney T, Pattou F, Kerr-Conte J, Donath MY, Bruun C, Mandrup-Poulsen T, Billestrup N, Halban PA. Parnaud G, et al. Among authors: donath my. Diabetologia. 2008 Jan;51(1):91-100. doi: 10.1007/s00125-007-0855-1. Epub 2007 Nov 10. Diabetologia. 2008. PMID: 17994216
Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.
Böni-Schnetzler M, Thorne J, Parnaud G, Marselli L, Ehses JA, Kerr-Conte J, Pattou F, Halban PA, Weir GC, Donath MY. Böni-Schnetzler M, et al. Among authors: donath my. J Clin Endocrinol Metab. 2008 Oct;93(10):4065-74. doi: 10.1210/jc.2008-0396. Epub 2008 Jul 29. J Clin Endocrinol Metab. 2008. PMID: 18664535 Free PMC article.
Insulitis in type 2 diabetes.
Böni-Schnetzler M, Ehses JA, Faulenbach M, Donath MY. Böni-Schnetzler M, et al. Among authors: donath my. Diabetes Obes Metab. 2008 Nov;10 Suppl 4:201-4. doi: 10.1111/j.1463-1326.2008.00950.x. Diabetes Obes Metab. 2008. PMID: 18834448
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