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Recent developments in bisintercalator natural products.
Zolova OE, Mady AS, Garneau-Tsodikova S. Zolova OE, et al. Among authors: mady as. Biopolymers. 2010 Sep;93(9):777-90. doi: 10.1002/bip.21489. Biopolymers. 2010. PMID: 20578002 Free article. Review.
3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation.
Abulwerdi FA, Liao C, Mady AS, Gavin J, Shen C, Cierpicki T, Stuckey JA, Showalter HD, Nikolovska-Coleska Z. Abulwerdi FA, et al. Among authors: mady as. J Med Chem. 2014 May 22;57(10):4111-33. doi: 10.1021/jm500010b. Epub 2014 May 7. J Med Chem. 2014. PMID: 24749893 Free PMC article.
Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins.
Kump KJ, Miao L, Mady ASA, Ansari NH, Shrestha UK, Yang Y, Pal M, Liao C, Perdih A, Abulwerdi FA, Chinnaswamy K, Meagher JL, Carlson JM, Khanna M, Stuckey JA, Nikolovska-Coleska Z. Kump KJ, et al. Among authors: mady asa. J Med Chem. 2020 Mar 12;63(5):2489-2510. doi: 10.1021/acs.jmedchem.9b01442. Epub 2020 Feb 14. J Med Chem. 2020. PMID: 31971799 Free PMC article.
A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo.
Abulwerdi F, Liao C, Liu M, Azmi AS, Aboukameel A, Mady AS, Gulappa T, Cierpicki T, Owens S, Zhang T, Sun D, Stuckey JA, Mohammad RM, Nikolovska-Coleska Z. Abulwerdi F, et al. Among authors: mady as. Mol Cancer Ther. 2014 Mar;13(3):565-75. doi: 10.1158/1535-7163.MCT-12-0767. Epub 2013 Sep 9. Mol Cancer Ther. 2014. PMID: 24019208 Free PMC article.
The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics.
Giblin W, Bringman-Rodenbarger L, Guo AH, Kumar S, Monovich AC, Mostafa AM, Skinner ME, Azar M, Mady AS, Chung CH, Kadambi N, Melong KA, Lee HJ, Zhang L, Sajjakulnukit P, Trefely S, Varner EL, Iyer S, Wang M, Wilmott JS, Soyer HP, Sturm RA, Pritchard AL, Andea AA, Scolyer RA, Stark MS, Scott DA, Fullen DR, Bosenberg MW, Chandrasekaran S, Nikolovska-Coleska Z, Verhaegen ME, Snyder NW, Rivera MN, Osterman AL, Lyssiotis CA, Lombard DB. Giblin W, et al. Among authors: mady as. J Clin Invest. 2021 Jun 15;131(12):e138926. doi: 10.1172/JCI138926. J Clin Invest. 2021. PMID: 33945506 Free PMC article.
PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity.
Gozgit JM, Vasbinder MM, Abo RP, Kunii K, Kuplast-Barr KG, Gui B, Lu AZ, Molina JR, Minissale E, Swinger KK, Wigle TJ, Blackwell DJ, Majer CR, Ren Y, Niepel M, Varsamis ZA, Nayak SP, Bamberg E, Mo JR, Church WD, Mady ASA, Song J, Utley L, Rao PE, Mitchison TJ, Kuntz KW, Richon VM, Keilhack H. Gozgit JM, et al. Among authors: mady asa. Cancer Cell. 2021 Sep 13;39(9):1214-1226.e10. doi: 10.1016/j.ccell.2021.06.018. Epub 2021 Jul 22. Cancer Cell. 2021. PMID: 34375612 Free article.
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