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PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets.
Hou X, Kumar A, Lee C, Wang B, Arjunan P, Dong L, Maminishkis A, Tang Z, Li Y, Zhang F, Zhang SZ, Wardega P, Chakrabarty S, Liu B, Wu Z, Colosi P, Fariss RN, Lennartsson J, Nussenblatt R, Gutkind JS, Cao Y, Li X. Hou X, et al. Among authors: fariss rn. Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12216-21. doi: 10.1073/pnas.1004143107. Epub 2010 Jun 21. Proc Natl Acad Sci U S A. 2010. PMID: 20566880 Free PMC article.
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis.
Zhang F, Tang Z, Hou X, Lennartsson J, Li Y, Koch AW, Scotney P, Lee C, Arjunan P, Dong L, Kumar A, Rissanen TT, Wang B, Nagai N, Fons P, Fariss R, Zhang Y, Wawrousek E, Tansey G, Raber J, Fong GH, Ding H, Greenberg DA, Becker KG, Herbert JM, Nash A, Yla-Herttuala S, Cao Y, Watts RJ, Li X. Zhang F, et al. Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6152-7. doi: 10.1073/pnas.0813061106. Epub 2009 Apr 6. Proc Natl Acad Sci U S A. 2009. PMID: 19369214 Free PMC article.
Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation.
Tang Z, Arjunan P, Lee C, Li Y, Kumar A, Hou X, Wang B, Wardega P, Zhang F, Dong L, Zhang Y, Zhang SZ, Ding H, Fariss RN, Becker KG, Lennartsson J, Nagai N, Cao Y, Li X. Tang Z, et al. Among authors: fariss rn. J Exp Med. 2010 Apr 12;207(4):867-80. doi: 10.1084/jem.20091704. Epub 2010 Mar 15. J Exp Med. 2010. PMID: 20231377 Free PMC article.
Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity.
Palmer DC, Chan CC, Gattinoni L, Wrzesinski C, Paulos CM, Hinrichs CS, Powell DJ Jr, Klebanoff CA, Finkelstein SE, Fariss RN, Yu Z, Nussenblatt RB, Rosenberg SA, Restifo NP. Palmer DC, et al. Among authors: fariss rn. Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8061-6. doi: 10.1073/pnas.0710929105. Epub 2008 Jun 3. Proc Natl Acad Sci U S A. 2008. PMID: 18523011 Free PMC article.
128 results