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Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers.
Roberts KG, Smith AM, McDougall F, Carpenter H, Horan M, Neviani P, Powell JA, Thomas D, Guthridge MA, Perrotti D, Sim AT, Ashman LK, Verrills NM. Roberts KG, et al. Among authors: sim at. Cancer Res. 2010 Jul 1;70(13):5438-47. doi: 10.1158/0008-5472.CAN-09-2544. Epub 2010 Jun 15. Cancer Res. 2010. PMID: 20551067 Free PMC article.
The complex nature of protein phosphatases.
Sim AT, Ludowyke RI. Sim AT, et al. IUBMB Life. 2002 Jun;53(6):283-6. doi: 10.1080/15216540213462. IUBMB Life. 2002. PMID: 12625365 Free article. Review.
48 results