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Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers.
Roberts KG, Smith AM, McDougall F, Carpenter H, Horan M, Neviani P, Powell JA, Thomas D, Guthridge MA, Perrotti D, Sim AT, Ashman LK, Verrills NM. Roberts KG, et al. Among authors: perrotti d. Cancer Res. 2010 Jul 1;70(13):5438-47. doi: 10.1158/0008-5472.CAN-09-2544. Epub 2010 Jun 15. Cancer Res. 2010. PMID: 20551067 Free PMC article.
SETting OP449 into the PP2A-activating drug family.
Neviani P, Perrotti D. Neviani P, et al. Among authors: perrotti d. Clin Cancer Res. 2014 Apr 15;20(8):2026-8. doi: 10.1158/1078-0432.CCR-14-0166. Epub 2014 Mar 14. Clin Cancer Res. 2014. PMID: 24634375 Free PMC article.
FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia.
Neviani P, Santhanam R, Oaks JJ, Eiring AM, Notari M, Blaser BW, Liu S, Trotta R, Muthusamy N, Gambacorti-Passerini C, Druker BJ, Cortes J, Marcucci G, Chen CS, Verrills NM, Roy DC, Caligiuri MA, Bloomfield CD, Byrd JC, Perrotti D. Neviani P, et al. Among authors: perrotti d. J Clin Invest. 2007 Sep;117(9):2408-21. doi: 10.1172/JCI31095. J Clin Invest. 2007. PMID: 17717597 Free PMC article.
The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein.
Neviani P, Santhanam R, Trotta R, Notari M, Blaser BW, Liu S, Mao H, Chang JS, Galietta A, Uttam A, Roy DC, Valtieri M, Bruner-Klisovic R, Caligiuri MA, Bloomfield CD, Marcucci G, Perrotti D. Neviani P, et al. Among authors: perrotti d. Cancer Cell. 2005 Nov;8(5):355-68. doi: 10.1016/j.ccr.2005.10.015. Cancer Cell. 2005. PMID: 16286244 Free article.
134 results