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Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers.
Roberts KG, Smith AM, McDougall F, Carpenter H, Horan M, Neviani P, Powell JA, Thomas D, Guthridge MA, Perrotti D, Sim AT, Ashman LK, Verrills NM. Roberts KG, et al. Among authors: ashman lk. Cancer Res. 2010 Jul 1;70(13):5438-47. doi: 10.1158/0008-5472.CAN-09-2544. Epub 2010 Jun 15. Cancer Res. 2010. PMID: 20551067 Free PMC article.
Resistance to c-KIT kinase inhibitors conferred by V654A mutation.
Roberts KG, Odell AF, Byrnes EM, Baleato RM, Griffith R, Lyons AB, Ashman LK. Roberts KG, et al. Among authors: ashman lk. Mol Cancer Ther. 2007 Mar;6(3):1159-66. doi: 10.1158/1535-7163.MCT-06-0641. Mol Cancer Ther. 2007. PMID: 17363509
Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors.
Smith AM, Dun MD, Lee EM, Harrison C, Kahl R, Flanagan H, Panicker N, Mashkani B, Don AS, Morris J, Toop H, Lock RB, Powell JA, Thomas D, Guthridge MA, Moore A, Ashman LK, Skelding KA, Enjeti A, Verrills NM. Smith AM, et al. Among authors: ashman lk. Oncotarget. 2016 Jul 26;7(30):47465-47478. doi: 10.18632/oncotarget.10167. Oncotarget. 2016. PMID: 27329844 Free PMC article.
Therapeutic targeting of c-KIT in cancer.
Ashman LK, Griffith R. Ashman LK, et al. Expert Opin Investig Drugs. 2013 Jan;22(1):103-15. doi: 10.1517/13543784.2013.740010. Epub 2012 Nov 6. Expert Opin Investig Drugs. 2013. PMID: 23127174 Review.
157 results