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Characterization of golimumab, a human monoclonal antibody specific for human tumor necrosis factor α.
Shealy DJ, Cai A, Staquet K, Baker A, Lacy ER, Johns L, Vafa O, Gunn G 3rd, Tam S, Sague S, Wang D, Brigham-Burke M, Dalmonte P, Emmell E, Pikounis B, Bugelski PJ, Zhou H, Scallon BJ, Giles-Komar J. Shealy DJ, et al. Among authors: brigham burke m. MAbs. 2010 Jul-Aug;2(4):428-39. doi: 10.4161/mabs.12304. Epub 2010 Jul 1. MAbs. 2010. PMID: 20519961 Free PMC article.
Down modulation of human TLR3 function by a monoclonal antibody.
Duffy KE, Lamb RJ, San Mateo LR, Jordan JL, Canziani G, Brigham-Burke M, Korteweg J, Cunningham M, Beck HS, Carton J, Giles-Komar J, Duchala C, Sarisky RT, Mbow ML. Duffy KE, et al. Among authors: brigham burke m. Cell Immunol. 2007 Aug;248(2):103-14. doi: 10.1016/j.cellimm.2007.10.002. Epub 2007 Nov 28. Cell Immunol. 2007. PMID: 18048020
Engineering human IL-18 with increased bioactivity and bioavailability.
Swencki-Underwood B, Cunningham MR, Heavner GA, Blasie C, McCarthy SG, Dougherty T, Brigham-Burke M, Gunn GR, Goletz TJ, Snyder LA. Swencki-Underwood B, et al. Among authors: brigham burke m. Cytokine. 2006 Apr;34(1-2):114-24. doi: 10.1016/j.cyto.2006.04.004. Cytokine. 2006. PMID: 16750378
Modification of the Fc region of a primatized IgG antibody to human CD4 retains its ability to modulate CD4 receptors but does not deplete CD4(+) T cells in chimpanzees.
Newman R, Hariharan K, Reff M, Anderson DR, Braslawsky G, Santoro D, Hanna N, Bugelski PJ, Brigham-Burke M, Crysler C, Gagnon RC, Dal Monte P, Doyle ML, Hensley PC, Reddy MP, Sweet RW, Truneh A. Newman R, et al. Clin Immunol. 2001 Feb;98(2):164-74. doi: 10.1006/clim.2000.4975. Clin Immunol. 2001. PMID: 11161972
31 results