Sümegi B - Search Results

1

A novel PARP inhibitor L-2286 in a rat model of impact acceleration head injury: an immunohistochemical and behavioral study.

Kövesdi E, Bukovics P, Besson V, Nyirádi J, Lückl J, Pál J, Sümegi B, Dóczi T, Hernádi I, Büki A. Kövesdi E, et al. Among authors: sumegi b. Int J Mol Sci. 2010 Mar 26;11(4):1253-68. doi: 10.3390/ijms11041253. Int J Mol Sci. 2010. PMID: 20480019 Free PMC article.

2

Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases.

Berger NA, Besson VC, Boulares AH, Bürkle A, Chiarugi A, Clark RS, Curtin NJ, Cuzzocrea S, Dawson TM, Dawson VL, Haskó G, Liaudet L, Moroni F, Pacher P, Radermacher P, Salzman AL, Snyder SH, Soriano FG, Strosznajder RP, Sümegi B, Swanson RA, Szabo C. Berger NA, et al. Among authors: sumegi b. Br J Pharmacol. 2018 Jan;175(2):192-222. doi: 10.1111/bph.13748. Epub 2017 Mar 26. Br J Pharmacol. 2018. PMID: 28213892 Free PMC article. Review.

3

Mitochondrial Protection by PARP Inhibition.

Gallyas F Jr, Sumegi B. Gallyas F Jr, et al. Among authors: sumegi b. Int J Mol Sci. 2020 Apr 16;21(8):2767. doi: 10.3390/ijms21082767. Int J Mol Sci. 2020. PMID: 32316192 Free PMC article. Review.

4

The role of Akt and mitogen-activated protein kinase systems in the protective effect of poly(ADP-ribose) polymerase inhibition in Langendorff perfused and in isoproterenol-damaged rat hearts.

Pálfi A, Tóth A, Kulcsár G, Hantó K, Deres P, Bartha E, Halmosi R, Szabados E, Czopf L, Kálai T, Hideg K, Sümegi B, Tóth K. Pálfi A, et al. Among authors: sumegi b. J Pharmacol Exp Ther. 2005 Oct;315(1):273-82. doi: 10.1124/jpet.105.088336. Epub 2005 Jun 10. J Pharmacol Exp Ther. 2005. PMID: 15951400

5

Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system.

Halmosi R, Berente Z, Osz E, Toth K, Literati-Nagy P, Sumegi B. Halmosi R, et al. Among authors: sumegi b. Mol Pharmacol. 2001 Jun;59(6):1497-505. doi: 10.1124/mol.59.6.1497. Mol Pharmacol. 2001. PMID: 11353811

6

PARP inhibition prevents postinfarction myocardial remodeling and heart failure via the protein kinase C/glycogen synthase kinase-3beta pathway.

Palfi A, Toth A, Hanto K, Deres P, Szabados E, Szereday Z, Kulcsar G, Kalai T, Hideg K, Gallyas F Jr, Sumegi B, Toth K, Halmosi R. Palfi A, et al. Among authors: sumegi b. J Mol Cell Cardiol. 2006 Jul;41(1):149-59. doi: 10.1016/j.yjmcc.2006.03.427. Epub 2006 May 23. J Mol Cell Cardiol. 2006. PMID: 16716347

7

Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation.

Radnai B, Antus C, Racz B, Engelmann P, Priber JK, Tucsek Z, Veres B, Turi Z, Lorand T, Sumegi B, Gallyas F Jr. Radnai B, et al. Among authors: sumegi b. Mol Cancer. 2012 May 14;11:34. doi: 10.1186/1476-4598-11-34. Mol Cancer. 2012. PMID: 22583868 Free PMC article.

8

Effect of L-2286, a poly(ADP-ribose)polymerase inhibitor and enalapril on myocardial remodeling and heart failure.

Bartha E, Kiss GN, Kalman E, Kulcsár G, Kálai T, Hideg K, Habon T, Sumegi B, Toth K, Halmosi R. Bartha E, et al. Among authors: sumegi b. J Cardiovasc Pharmacol. 2008 Sep;52(3):253-61. doi: 10.1097/FJC.0b013e3181855cef. J Cardiovasc Pharmacol. 2008. PMID: 18806606

9

PARP-inhibitor treatment prevents hypertension induced cardiac remodeling by favorable modulation of heat shock proteins, Akt-1/GSK-3β and several PKC isoforms.

Deres L, Bartha E, Palfi A, Eros K, Riba A, Lantos J, Kalai T, Hideg K, Sumegi B, Gallyas F, Toth K, Halmosi R. Deres L, et al. Among authors: sumegi b. PLoS One. 2014 Jul 11;9(7):e102148. doi: 10.1371/journal.pone.0102148. eCollection 2014. PLoS One. 2014. PMID: 25014216 Free PMC article.

10

PARP inhibition attenuates acute kidney allograft rejection by suppressing cell death pathways and activating PI-3K-Akt cascade.

Kalmar-Nagy K, Degrell P, Szabo A, Sumegi K, Wittmann I, Gallyas F Jr, Sumegi B. Kalmar-Nagy K, et al. Among authors: sumegi k, sumegi b. PLoS One. 2013 Dec 3;8(12):e81928. doi: 10.1371/journal.pone.0081928. eCollection 2013. PLoS One. 2013. PMID: 24312605 Free PMC article.

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