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On the inhibition of histone deacetylase 8.
Estiu G, West N, Mazitschek R, Greenberg E, Bradner JE, Wiest O. Estiu G, et al. Among authors: mazitschek r. Bioorg Med Chem. 2010 Jun 1;18(11):4103-10. doi: 10.1016/j.bmc.2010.03.080. Epub 2010 Apr 3. Bioorg Med Chem. 2010. PMID: 20472442 Free PMC article.
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.
Bradner JE, Mak R, Tanguturi SK, Mazitschek R, Haggarty SJ, Ross K, Chang CY, Bosco J, West N, Morse E, Lin K, Shen JP, Kwiatkowski NP, Gheldof N, Dekker J, DeAngelo DJ, Carr SA, Schreiber SL, Golub TR, Ebert BL. Bradner JE, et al. Among authors: mazitschek r. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12617-22. doi: 10.1073/pnas.1006774107. Epub 2010 Jun 28. Proc Natl Acad Sci U S A. 2010. PMID: 20616024 Free PMC article.
Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma.
Hideshima T, Qi J, Paranal RM, Tang W, Greenberg E, West N, Colling ME, Estiu G, Mazitschek R, Perry JA, Ohguchi H, Cottini F, Mimura N, Görgün G, Tai YT, Richardson PG, Carrasco RD, Wiest O, Schreiber SL, Anderson KC, Bradner JE. Hideshima T, et al. Among authors: mazitschek r. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13162-13167. doi: 10.1073/pnas.1608067113. Epub 2016 Oct 31. Proc Natl Acad Sci U S A. 2016. PMID: 27799547 Free PMC article.
Syntheses and discovery of a novel class of cinnamic hydroxamates as histone deacetylase inhibitors by multimodality molecular imaging in living subjects.
Chan CT, Qi J, Smith W, Paranol R, Mazitschek R, West N, Reeves R, Chiosis G, Schreiber SL, Bradner JE, Paulmurugan R, Gambhir SS. Chan CT, et al. Among authors: mazitschek r. Cancer Res. 2014 Dec 15;74(24):7475-86. doi: 10.1158/0008-5472.CAN-14-0197. Epub 2014 Oct 15. Cancer Res. 2014. PMID: 25320008 Free PMC article.
Chemical phylogenetics of histone deacetylases.
Bradner JE, West N, Grachan ML, Greenberg EF, Haggarty SJ, Warnow T, Mazitschek R. Bradner JE, et al. Among authors: mazitschek r. Nat Chem Biol. 2010 Mar;6(3):238-243. doi: 10.1038/nchembio.313. Epub 2010 Feb 7. Nat Chem Biol. 2010. PMID: 20139990 Free PMC article.
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.
Herman JD, Pepper LR, Cortese JF, Estiu G, Galinsky K, Zuzarte-Luis V, Derbyshire ER, Ribacke U, Lukens AK, Santos SA, Patel V, Clish CB, Sullivan WJ Jr, Zhou H, Bopp SE, Schimmel P, Lindquist S, Clardy J, Mota MM, Keller TL, Whitman M, Wiest O, Wirth DF, Mazitschek R. Herman JD, et al. Among authors: mazitschek r. Sci Transl Med. 2015 May 20;7(288):288ra77. doi: 10.1126/scitranslmed.aaa3575. Sci Transl Med. 2015. PMID: 25995223 Free PMC article.
Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells.
Aldana-Masangkay GI, Rodriguez-Gonzalez A, Lin T, Ikeda AK, Hsieh YT, Kim YM, Lomenick B, Okemoto K, Landaw EM, Wang D, Mazitschek R, Bradner JE, Sakamoto KM. Aldana-Masangkay GI, et al. Among authors: mazitschek r. Leuk Lymphoma. 2011 Aug;52(8):1544-55. doi: 10.3109/10428194.2011.570821. Epub 2011 Jun 23. Leuk Lymphoma. 2011. PMID: 21699378 Free PMC article.
130 results