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Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia.
Valdez CA, Tripp JC, Miyamoto Y, Kalisiak J, Hruz P, Andersen YS, Brown SE, Kangas K, Arzu LV, Davids BJ, Gillin FD, Upcroft JA, Upcroft P, Fokin VV, Smith DK, Sharpless KB, Eckmann L. Valdez CA, et al. Among authors: eckmann l. J Med Chem. 2009 Jul 9;52(13):4038-53. doi: 10.1021/jm900356n. J Med Chem. 2009. PMID: 19480409 Free PMC article.
Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia.
Leitsch D, Burgess AG, Dunn LA, Krauer KG, Tan K, Duchêne M, Upcroft P, Eckmann L, Upcroft JA. Leitsch D, et al. Among authors: eckmann l. J Antimicrob Chemother. 2011 Aug;66(8):1756-65. doi: 10.1093/jac/dkr192. Epub 2011 May 22. J Antimicrob Chemother. 2011. PMID: 21602576 Free PMC article.
305 results