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Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia.
Leitsch D, Burgess AG, Dunn LA, Krauer KG, Tan K, Duchêne M, Upcroft P, Eckmann L, Upcroft JA. Leitsch D, et al. Among authors: burgess ag. J Antimicrob Chemother. 2011 Aug;66(8):1756-65. doi: 10.1093/jac/dkr192. Epub 2011 May 22. J Antimicrob Chemother. 2011. PMID: 21602576 Free PMC article.
The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation.
Fernandez-Rojo MA, Pearen MA, Burgess AG, Ikonomopoulou MP, Hoang-Le D, Genz B, Saggiomo SL, Nawaratna SSK, Poli M, Reissmann R, Gobert GN, Deutsch U, Engelhardt B, Brooks AJ, Jones A, Arosio P, Ramm GA. Fernandez-Rojo MA, et al. Among authors: burgess ag. Sci Signal. 2024 Apr 2;17(830):eade4335. doi: 10.1126/scisignal.ade4335. Epub 2024 Apr 2. Sci Signal. 2024. PMID: 38564492
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