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Multivalent antibodies: when design surpasses evolution.
Cuesta AM, Sainz-Pastor N, Bonet J, Oliva B, Alvarez-Vallina L. Cuesta AM, et al. Among authors: bonet j. Trends Biotechnol. 2010 Jul;28(7):355-62. doi: 10.1016/j.tibtech.2010.03.007. Epub 2010 May 4. Trends Biotechnol. 2010. PMID: 20447706 Review.
Prediction of a new class of RNA recognition motif.
Cerdà-Costa N, Bonet J, Fernández MR, Avilés FX, Oliva B, Villegas S. Cerdà-Costa N, et al. Among authors: bonet j. J Mol Model. 2011 Aug;17(8):1863-75. doi: 10.1007/s00894-010-0888-0. Epub 2010 Nov 17. J Mol Model. 2011. PMID: 21082207
Generation and characterization of monospecific and bispecific hexavalent trimerbodies.
Blanco-Toribio A, Sainz-Pastor N, Álvarez-Cienfuegos A, Merino N, Cuesta ÁM, Sánchez-Martín D, Bonet J, Santos-Valle P, Sanz L, Oliva B, Blanco FJ, Álvarez-Vallina L. Blanco-Toribio A, et al. Among authors: bonet j. MAbs. 2013 Jan-Feb;5(1):70-9. doi: 10.4161/mabs.22698. Epub 2012 Dec 5. MAbs. 2013. PMID: 23221741 Free PMC article.
Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains.
Alvarez-Cienfuegos A, Nuñez-Prado N, Compte M, Cuesta AM, Blanco-Toribio A, Harwood SL, Villate M, Merino N, Bonet J, Navarro R, Muñoz-Briones C, Sørensen KM, Mølgaard K, Oliva B, Sanz L, Blanco FJ, Alvarez-Vallina L. Alvarez-Cienfuegos A, et al. Among authors: bonet j. Sci Rep. 2016 Jun 27;6:28643. doi: 10.1038/srep28643. Sci Rep. 2016. PMID: 27345490 Free PMC article.
The antigen-binding fragment of human gamma immunoglobulin prevents amyloid β-peptide folding into β-sheet to form oligomers.
Valls-Comamala V, Guivernau B, Bonet J, Puig M, Perálvarez-Marín A, Palomer E, Fernàndez-Busquets X, Altafaj X, Tajes M, Puig-Pijoan A, Vicente R, Oliva B, Muñoz FJ. Valls-Comamala V, et al. Among authors: bonet j. Oncotarget. 2017 Jun 20;8(25):41154-41165. doi: 10.18632/oncotarget.17074. Oncotarget. 2017. PMID: 28467807 Free PMC article.
ATTACK, a novel bispecific T cell-recruiting antibody with trivalent EGFR binding and monovalent CD3 binding for cancer immunotherapy.
Harwood SL, Alvarez-Cienfuegos A, Nuñez-Prado N, Compte M, Hernández-Pérez S, Merino N, Bonet J, Navarro R, Van Bergen En Henegouwen PMP, Lykkemark S, Mikkelsen K, Mølgaard K, Jabs F, Sanz L, Blanco FJ, Roda-Navarro P, Alvarez-Vallina L. Harwood SL, et al. Among authors: bonet j. Oncoimmunology. 2017 Sep 27;7(1):e1377874. doi: 10.1080/2162402X.2017.1377874. eCollection 2017. Oncoimmunology. 2017. PMID: 29296540 Free PMC article.
Bispecific light T-cell engagers for gene-based immunotherapy of epidermal growth factor receptor (EGFR)-positive malignancies.
Mølgaard K, Harwood SL, Compte M, Merino N, Bonet J, Alvarez-Cienfuegos A, Mikkelsen K, Nuñez-Prado N, Alvarez-Mendez A, Sanz L, Blanco FJ, Alvarez-Vallina L. Mølgaard K, et al. Among authors: bonet j. Cancer Immunol Immunother. 2018 Aug;67(8):1251-1260. doi: 10.1007/s00262-018-2181-5. Epub 2018 Jun 4. Cancer Immunol Immunother. 2018. PMID: 29869168 Free PMC article.
262 results