Ilies M - Search Results

1

2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I.

Ilies M, Di Costanzo L, North ML, Scott JA, Christianson DW. Ilies M, et al. J Med Chem. 2010 May 27;53(10):4266-76. doi: 10.1021/jm100306a. J Med Chem. 2010. PMID: 20441173 Free PMC article.

2

Inhibition of human arginase I by substrate and product analogues.

Di Costanzo L, Ilies M, Thorn KJ, Christianson DW. Di Costanzo L, et al. Among authors: ilies m. Arch Biochem Biophys. 2010 Apr 15;496(2):101-8. doi: 10.1016/j.abb.2010.02.004. Epub 2010 Feb 12. Arch Biochem Biophys. 2010. PMID: 20153713 Free PMC article.

3

Binding of α,α-disubstituted amino acids to arginase suggests new avenues for inhibitor design.

Ilies M, Di Costanzo L, Dowling DP, Thorn KJ, Christianson DW. Ilies M, et al. J Med Chem. 2011 Aug 11;54(15):5432-43. doi: 10.1021/jm200443b. Epub 2011 Jul 18. J Med Chem. 2011. PMID: 21728378 Free PMC article.

4

Synthesis of a new trifluoromethylketone analogue of l-arginine and contrasting inhibitory activity against human arginase I and histone deacetylase 8.

Ilies M, Dowling DP, Lombardi PM, Christianson DW. Ilies M, et al. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5854-8. doi: 10.1016/j.bmcl.2011.07.100. Epub 2011 Aug 3. Bioorg Med Chem Lett. 2011. PMID: 21875805 Free PMC article.

5

Crystal structure of arginase from Plasmodium falciparum and implications for L-arginine depletion in malarial infection.

Dowling DP, Ilies M, Olszewski KL, Portugal S, Mota MM, Llinás M, Christianson DW. Dowling DP, et al. Among authors: ilies m. Biochemistry. 2010 Jul 6;49(26):5600-8. doi: 10.1021/bi100390z. Biochemistry. 2010. PMID: 20527960 Free PMC article.

6

Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats.

Kim JH, Bugaj LJ, Oh YJ, Bivalacqua TJ, Ryoo S, Soucy KG, Santhanam L, Webb A, Camara A, Sikka G, Nyhan D, Shoukas AA, Ilies M, Christianson DW, Champion HC, Berkowitz DE. Kim JH, et al. Among authors: ilies m. J Appl Physiol (1985). 2009 Oct;107(4):1249-57. doi: 10.1152/japplphysiol.91393.2008. Epub 2009 Aug 6. J Appl Physiol (1985). 2009. PMID: 19661445 Free PMC article.

7

Endothelial arginase II: a novel target for the treatment of atherosclerosis.

Ryoo S, Gupta G, Benjo A, Lim HK, Camara A, Sikka G, Lim HK, Sohi J, Santhanam L, Soucy K, Tuday E, Baraban E, Ilies M, Gerstenblith G, Nyhan D, Shoukas A, Christianson DW, Alp NJ, Champion HC, Huso D, Berkowitz DE. Ryoo S, et al. Among authors: ilies m. Circ Res. 2008 Apr 25;102(8):923-32. doi: 10.1161/CIRCRESAHA.107.169573. Epub 2008 Feb 28. Circ Res. 2008. PMID: 18309100

8

Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis.

Herbert DR, Orekov T, Roloson A, Ilies M, Perkins C, O'Brien W, Cederbaum S, Christianson DW, Zimmermann N, Rothenberg ME, Finkelman FD. Herbert DR, et al. Among authors: ilies m. J Immunol. 2010 Jun 1;184(11):6438-46. doi: 10.4049/jimmunol.0902009. Epub 2010 May 5. J Immunol. 2010. PMID: 20483789 Free PMC article.

9

Carbonic anhydrase activators: design of high affinity isozymes I, II, and IV activators, incorporating tri-/tetrasubstituted-pyridinium-azole moieties.

Ilies M, Banciu MD, Ilies MA, Scozzafava A, Caproiu MT, Supuran CT. Ilies M, et al. Among authors: ilies ma. J Med Chem. 2002 Jan 17;45(2):504-10. doi: 10.1021/jm011031n. J Med Chem. 2002. PMID: 11784154

10

Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.

Ilies MA, Vullo D, Pastorek J, Scozzafava A, Ilies M, Caproiu MT, Pastorekova S, Supuran CT. Ilies MA, et al. Among authors: ilies m. J Med Chem. 2003 May 22;46(11):2187-96. doi: 10.1021/jm021123s. J Med Chem. 2003. PMID: 12747790

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