Yan M - Search Results

1

Therapeutic antibody targeting of individual Notch receptors.

Wu Y, Cain-Hom C, Choy L, Hagenbeek TJ, de Leon GP, Chen Y, Finkle D, Venook R, Wu X, Ridgway J, Schahin-Reed D, Dow GJ, Shelton A, Stawicki S, Watts RJ, Zhang J, Choy R, Howard P, Kadyk L, Yan M, Zha J, Callahan CA, Hymowitz SG, Siebel CW. Wu Y, et al. Among authors: yan m. Nature. 2010 Apr 15;464(7291):1052-7. doi: 10.1038/nature08878. Nature. 2010. PMID: 20393564

2

Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity.

Yan M, Marsters SA, Grewal IS, Wang H, Ashkenazi A, Dixit VM. Yan M, et al. Nat Immunol. 2000 Jul;1(1):37-41. doi: 10.1038/76889. Nat Immunol. 2000. PMID: 10881172

3

Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors.

Yan M, Wang LC, Hymowitz SG, Schilbach S, Lee J, Goddard A, de Vos AM, Gao WQ, Dixit VM. Yan M, et al. Science. 2000 Oct 20;290(5491):523-7. doi: 10.1126/science.290.5491.523. Science. 2000. PMID: 11039935

4

TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice.

Wang H, Marsters SA, Baker T, Chan B, Lee WP, Fu L, Tumas D, Yan M, Dixit VM, Ashkenazi A, Grewal IS. Wang H, et al. Among authors: yan m. Nat Immunol. 2001 Jul;2(7):632-7. doi: 10.1038/89782. Nat Immunol. 2001. PMID: 11429548

5

Activation and accumulation of B cells in TACI-deficient mice.

Yan M, Wang H, Chan B, Roose-Girma M, Erickson S, Baker T, Tumas D, Grewal IS, Dixit VM. Yan M, et al. Nat Immunol. 2001 Jul;2(7):638-43. doi: 10.1038/89790. Nat Immunol. 2001. PMID: 11429549

6

BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site.

Gordon NC, Pan B, Hymowitz SG, Yin J, Kelley RF, Cochran AG, Yan M, Dixit VM, Fairbrother WJ, Starovasnik MA. Gordon NC, et al. Among authors: yan m. Biochemistry. 2003 May 27;42(20):5977-83. doi: 10.1021/bi034017g. Biochemistry. 2003. PMID: 12755599

Several of the key BAFF-binding residues are presented from a beta-turn that we have shown previously to be sufficient for ligand binding when transferred to a structured beta-hairpin scaffold [Kayagaki, N., Yan, M., Seshasayee, D., Wang, H., Lee, W., French, D. …

Several of the key BAFF-binding residues are presented from a beta-turn that we have shown previously to be sufficient for ligand binding wh …

7

The crystal structures of EDA-A1 and EDA-A2: splice variants with distinct receptor specificity.

Hymowitz SG, Compaan DM, Yan M, Wallweber HJ, Dixit VM, Starovasnik MA, de Vos AM. Hymowitz SG, et al. Among authors: yan m. Structure. 2003 Dec;11(12):1513-20. doi: 10.1016/j.str.2003.11.009. Structure. 2003. PMID: 14656435 Free article.

8

Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding.

Hymowitz SG, Patel DR, Wallweber HJ, Runyon S, Yan M, Yin J, Shriver SK, Gordon NC, Pan B, Skelton NJ, Kelley RF, Starovasnik MA. Hymowitz SG, et al. Among authors: yan m. J Biol Chem. 2005 Feb 25;280(8):7218-27. doi: 10.1074/jbc.M411714200. Epub 2004 Nov 12. J Biol Chem. 2005. PMID: 15542592 Free article.

9

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis.

Ridgway J, Zhang G, Wu Y, Stawicki S, Liang WC, Chanthery Y, Kowalski J, Watts RJ, Callahan C, Kasman I, Singh M, Chien M, Tan C, Hongo JA, de Sauvage F, Plowman G, Yan M. Ridgway J, et al. Among authors: yan m. Nature. 2006 Dec 21;444(7122):1083-7. doi: 10.1038/nature05313. Nature. 2006. PMID: 17183323

10

Delta-like 4/Notch signaling and its therapeutic implications.

Yan M, Plowman GD. Yan M, et al. Clin Cancer Res. 2007 Dec 15;13(24):7243-6. doi: 10.1158/1078-0432.CCR-07-1393. Clin Cancer Res. 2007. PMID: 18094402 Review.

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