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Chimeric microtubule disruptors.
Chem Commun (Camb). 2010 May 7;46(17):2907-9. doi: 10.1039/c002558e. Epub 2010 Mar 20.
Chem Commun (Camb). 2010.
PMID: 20386818
3,17-disubstituted 2-alkylestra-1,3,5(10)-trien-3-ol derivatives: synthesis, in vitro and in vivo anticancer activity.
Bubert C, Leese MP, Mahon MF, Ferrandis E, Regis-Lydi S, Kasprzyk PG, Newman SP, Ho YT, Purohit A, Reed MJ, Potter BV.
Bubert C, et al. Among authors: regis lydi s.
J Med Chem. 2007 Sep 6;50(18):4431-43. doi: 10.1021/jm070405v. Epub 2007 Aug 15.
J Med Chem. 2007.
PMID: 17696419
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Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents.
Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BV.
Leese MP, et al. Among authors: regis lydi s.
J Med Chem. 2008 Mar 13;51(5):1295-308. doi: 10.1021/jm701319c. Epub 2008 Feb 9.
J Med Chem. 2008.
PMID: 18260615
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In vivo and in vitro properties of STX2484: a novel non-steroidal anti-cancer compound active in taxane-resistant breast cancer.
Stengel C, Newman SP, Day JM, Chander SK, Jourdan FL, Leese MP, Ferrandis E, Regis-Lydi S, Potter BV, Reed MJ, Purohit A, Foster PA.
Stengel C, et al. Among authors: regis lydi s.
Br J Cancer. 2014 Jul 15;111(2):300-8. doi: 10.1038/bjc.2014.188. Epub 2014 Jun 24.
Br J Cancer. 2014.
PMID: 24960406
Free PMC article.
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Effects of C-17 heterocyclic substituents on the anticancer activity of 2-ethylestra-1,3,5(10)-triene-3-O-sulfamates: synthesis, in vitro evaluation and computational modelling.
Jourdan F, Bubert C, Leese MP, Smith A, Ferrandis E, Regis-Lydi S, Newman SP, Purohit A, Reed MJ, Potter BV.
Jourdan F, et al. Among authors: regis lydi s.
Org Biomol Chem. 2008 Nov 21;6(22):4108-19. doi: 10.1039/b810300c. Epub 2008 Sep 22.
Org Biomol Chem. 2008.
PMID: 18972041
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