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(1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatment.
Kakinuma H, Oi T, Hashimoto-Tsuchiya Y, Arai M, Kawakita Y, Fukasawa Y, Iida I, Hagima N, Takeuchi H, Chino Y, Asami J, Okumura-Kitajima L, Io F, Yamamoto D, Miyata N, Takahashi T, Uchida S, Yamamoto K. Kakinuma H, et al. Among authors: yamamoto k, yamamoto d. J Med Chem. 2010 Apr 22;53(8):3247-61. doi: 10.1021/jm901893x. J Med Chem. 2010. PMID: 20302302
Synthesis and Structure-Activity Relationship of C-Phenyl D-Glucitol (TP0454614) Derivatives as Selective Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitors.
Kuroda S, Kobashi Y, Kawamura M, Kawabe K, Shiozawa F, Hamada M, Shimizu Y, Okumura-Kitajima L, Koretsune H, Kimura K, Yamamoto K, Kakinuma H. Kuroda S, et al. Among authors: yamamoto k. Chem Pharm Bull (Tokyo). 2020;68(7):635-652. doi: 10.1248/cpb.c20-00089. Chem Pharm Bull (Tokyo). 2020. PMID: 32611999 Free article.
(2S,4S)-4-Fluoro-1-{[(2-hydroxy-1,1-dimethylethyl)amino]acetyl}-pyrrolidine-2-carbonitrile monobenzenesulfonate (TS-021) is a selective and reversible dipeptidyl peptidase IV inhibitor.
Tajima A, Yamamoto K, Kozakai A, Okumura-Kitajima L, Mita Y, Kitano K, Jingu S, Nakaike S. Tajima A, et al. Among authors: yamamoto k. Eur J Pharmacol. 2011 Mar 25;655(1-3):99-107. doi: 10.1016/j.ejphar.2011.01.010. Epub 2011 Jan 22. Eur J Pharmacol. 2011. PMID: 21262219
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