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(1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatment.
Kakinuma H, Oi T, Hashimoto-Tsuchiya Y, Arai M, Kawakita Y, Fukasawa Y, Iida I, Hagima N, Takeuchi H, Chino Y, Asami J, Okumura-Kitajima L, Io F, Yamamoto D, Miyata N, Takahashi T, Uchida S, Yamamoto K. Kakinuma H, et al. Among authors: yamamoto k, yamamoto d. J Med Chem. 2010 Apr 22;53(8):3247-61. doi: 10.1021/jm901893x. J Med Chem. 2010. PMID: 20302302
Discovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group.
Chonan T, Wakasugi D, Yamamoto D, Yashiro M, Oi T, Tanaka H, Ohoka-Sugita A, Io F, Koretsune H, Hiratate A. Chonan T, et al. Among authors: yamamoto d. Bioorg Med Chem. 2011 Mar 1;19(5):1580-93. doi: 10.1016/j.bmc.2011.01.041. Epub 2011 Jan 27. Bioorg Med Chem. 2011. PMID: 21324704
(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.
Chonan T, Oi T, Yamamoto D, Yashiro M, Wakasugi D, Tanaka H, Ohoka-Sugita A, Io F, Koretsune H, Hiratate A. Chonan T, et al. Among authors: yamamoto d. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6645-8. doi: 10.1016/j.bmcl.2009.10.012. Epub 2009 Oct 8. Bioorg Med Chem Lett. 2009. PMID: 19853443
Synthetic (+)-terrein suppresses interleukin-6/soluble interleukin-6 receptor induced-secretion of vascular endothelial growth factor in human gingival fibroblasts.
Mandai H, Omori K, Yamamoto D, Tsumura T, Murota K, Yamamoto S, Mitsudo K, Ibaragi S, Sasaki A, Maeda H, Takashiba S, Suga S. Mandai H, et al. Among authors: yamamoto d, yamamoto s. Bioorg Med Chem. 2014 Oct 1;22(19):5338-44. doi: 10.1016/j.bmc.2014.07.047. Epub 2014 Aug 7. Bioorg Med Chem. 2014. PMID: 25151086
Synthesis and evaluation of N-alkyl-S-[3-(piperidin-1-yl)propyl]isothioureas: high affinity and human/rat species-selective histamine H(3) receptor antagonists.
Harusawa S, Sawada K, Magata T, Yoneyama H, Araki L, Usami Y, Hatano K, Yamamoto K, Yamamoto D, Yamatodani A. Harusawa S, et al. Among authors: yamamoto k, yamamoto d. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6415-20. doi: 10.1016/j.bmcl.2013.09.052. Epub 2013 Sep 26. Bioorg Med Chem Lett. 2013. PMID: 24140447 Free article.
Total synthesis and adjuvant activity of all stereoisomers of pinellic acid.
Shirahata T, Sunazuka T, Yoshida K, Yamamoto D, Harigaya Y, Nagai T, Kiyohara H, Yamada H, Kuwajima I, Omura S. Shirahata T, et al. Among authors: yamamoto d. Bioorg Med Chem Lett. 2003 Mar 10;13(5):937-41. doi: 10.1016/s0960-894x(02)01069-7. Bioorg Med Chem Lett. 2003. PMID: 12617925
741 results