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(1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatment.
Kakinuma H, Oi T, Hashimoto-Tsuchiya Y, Arai M, Kawakita Y, Fukasawa Y, Iida I, Hagima N, Takeuchi H, Chino Y, Asami J, Okumura-Kitajima L, Io F, Yamamoto D, Miyata N, Takahashi T, Uchida S, Yamamoto K. Kakinuma H, et al. J Med Chem. 2010 Apr 22;53(8):3247-61. doi: 10.1021/jm901893x. J Med Chem. 2010. PMID: 20302302
TS-071 is a novel, potent and selective renal sodium-glucose cotransporter 2 (SGLT2) inhibitor with anti-hyperglycaemic activity.
Yamamoto K, Uchida S, Kitano K, Fukuhara N, Okumura-Kitajima L, Gunji E, Kozakai A, Tomoike H, Kojima N, Asami J, Toyoda H, Arai M, Takahashi T, Takahashi K. Yamamoto K, et al. Among authors: okumura kitajima l. Br J Pharmacol. 2011 Sep;164(1):181-91. doi: 10.1111/j.1476-5381.2011.01340.x. Br J Pharmacol. 2011. PMID: 21410690 Free PMC article.
Synthesis and Structure-Activity Relationship of C-Phenyl D-Glucitol (TP0454614) Derivatives as Selective Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitors.
Kuroda S, Kobashi Y, Kawamura M, Kawabe K, Shiozawa F, Hamada M, Shimizu Y, Okumura-Kitajima L, Koretsune H, Kimura K, Yamamoto K, Kakinuma H. Kuroda S, et al. Among authors: okumura kitajima l. Chem Pharm Bull (Tokyo). 2020;68(7):635-652. doi: 10.1248/cpb.c20-00089. Chem Pharm Bull (Tokyo). 2020. PMID: 32611999 Free article.
Design, synthesis and biological evaluation of novel 1H-pyrazole-4-carbonyl-4,5,6,7-tetrahydrobenzo [b]thiophene derivatives as gut-selective NaPi2b inhibitors.
Ushiki Y, Kawabe K, Yamamoto-Okada K, Uneuchi F, Asanuma Y, Yamaguchi C, Ohta H, Shibata T, Abe T, Okumura-Kitajima L, Kosai Y, Endo M, Otake K, Munetomo E, Takahashi T, Kakinuma H. Ushiki Y, et al. Among authors: okumura kitajima l. Bioorg Med Chem Lett. 2022 Mar 1;59:128572. doi: 10.1016/j.bmcl.2022.128572. Epub 2022 Jan 21. Bioorg Med Chem Lett. 2022. PMID: 35066140
Design, synthesis and biological evaluation of novel pyridine derivatives as gut-selective NaPi2b inhibitors.
Ushiki Y, Kawabe K, Yamamoto-Okada K, Uneuchi F, Asanuma Y, Yamaguchi C, Ohta H, Shibata T, Abe T, Okumura-Kitajima L, Kosai Y, Endo M, Otake K, Munetomo E, Takahashi T, Kakinuma H. Ushiki Y, et al. Among authors: okumura kitajima l. Bioorg Med Chem Lett. 2022 Jun 1;65:128700. doi: 10.1016/j.bmcl.2022.128700. Epub 2022 Mar 25. Bioorg Med Chem Lett. 2022. PMID: 35346844
Design, synthesis and biological evaluation of novel indole derivatives as gut-selective NaPi2b inhibitors.
Ushiki Y, Kawabe K, Yamamoto-Okada K, Uneuchi F, Asanuma Y, Yamaguchi C, Ohta H, Shibata T, Abe T, Okumura-Kitajima L, Kosai Y, Endo M, Otake K, Munetomo E, Takahashi T, Kakinuma H. Ushiki Y, et al. Among authors: okumura kitajima l. Bioorg Med Chem. 2022 Jul 15;66:116783. doi: 10.1016/j.bmc.2022.116783. Epub 2022 May 2. Bioorg Med Chem. 2022. PMID: 35576656
Discovery of novel 2-[(4-hydroxy-6-oxo-2,3-dihydro-1H-pyridine-5-carbonyl)amino]acetic acid derivatives as HIF prolyl hydroxylase inhibitors for treatment of renal anemia.
Hamada M, Takayama T, Shibata T, Hiratate A, Takahashi M, Yashiro M, Takayama N, Okumura-Kitajima L, Koretsune H, Kajiyama H, Naruse T, Kato S, Takano H, Kakinuma H. Hamada M, et al. Among authors: okumura kitajima l. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1725-1730. doi: 10.1016/j.bmcl.2018.04.039. Epub 2018 Apr 16. Bioorg Med Chem Lett. 2018. PMID: 29681433
12 results