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Page 1
The molecular pathogenesis of Ewing's sarcoma.
Mackintosh C, Madoz-Gúrpide J, Ordóñez JL, Osuna D, Herrero-Martín D. Mackintosh C, et al. Among authors: ordonez jl. Cancer Biol Ther. 2010 May 1;9(9):655-67. doi: 10.4161/cbt.9.9.11511. Epub 2010 May 12. Cancer Biol Ther. 2010. PMID: 20215864 Review.
Stable interference of EWS-FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target.
Herrero-Martín D, Osuna D, Ordóñez JL, Sevillano V, Martins AS, Mackintosh C, Campos M, Madoz-Gúrpide J, Otero-Motta AP, Caballero G, Amaral AT, Wai DH, Braun Y, Eisenacher M, Schaefer KL, Poremba C, de Alava E. Herrero-Martín D, et al. Among authors: ordonez jl. Br J Cancer. 2009 Jul 7;101(1):80-90. doi: 10.1038/sj.bjc.6605104. Epub 2009 Jun 2. Br J Cancer. 2009. PMID: 19491900 Free PMC article.
A pivotal role for heat shock protein 90 in Ewing sarcoma resistance to anti-insulin-like growth factor 1 receptor treatment: in vitro and in vivo study.
Martins AS, Ordoñez JL, García-Sánchez A, Herrero D, Sevillano V, Osuna D, Mackintosh C, Caballero G, Otero AP, Poremba C, Madoz-Gúrpide J, de Alava E. Martins AS, et al. Among authors: ordonez jl. Cancer Res. 2008 Aug 1;68(15):6260-70. doi: 10.1158/0008-5472.CAN-07-3074. Cancer Res. 2008. PMID: 18676850
1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma.
Mackintosh C, Ordóñez JL, García-Domínguez DJ, Sevillano V, Llombart-Bosch A, Szuhai K, Scotlandi K, Alberghini M, Sciot R, Sinnaeve F, Hogendoorn PC, Picci P, Knuutila S, Dirksen U, Debiec-Rychter M, Schaefer KL, de Álava E. Mackintosh C, et al. Among authors: ordonez jl. Oncogene. 2012 Mar 8;31(10):1287-98. doi: 10.1038/onc.2011.317. Epub 2011 Aug 8. Oncogene. 2012. PMID: 21822310
Targeting sarcomas: therapeutic targets and their rational.
Ordóñez JL, Martins AS, Osuna D, Madoz-Gúrpide J, de Alava E. Ordóñez JL, et al. Semin Diagn Pathol. 2008 Nov;25(4):304-16. doi: 10.1053/j.semdp.2008.07.005. Semin Diagn Pathol. 2008. PMID: 19013896 Review.
The clinical relevance of molecular genetics in soft tissue sarcomas.
Ordóñez JL, Osuna D, García-Domínguez DJ, Amaral AT, Otero-Motta AP, Mackintosh C, Sevillano MV, Barbado MV, Hernández T, de Alava E. Ordóñez JL, et al. Adv Anat Pathol. 2010 May;17(3):162-81. doi: 10.1097/PAP.0b013e3181d98cbf. Adv Anat Pathol. 2010. PMID: 20418671 Review.
The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin.
Ordóñez JL, Amaral AT, Carcaboso AM, Herrero-Martín D, del Carmen García-Macías M, Sevillano V, Alonso D, Pascual-Pasto G, San-Segundo L, Vila-Ubach M, Rodrigues T, Fraile S, Teodosio C, Mayo-Iscar A, Aracil M, Galmarini CM, Tirado OM, Mora J, de Álava E. Ordóñez JL, et al. Oncotarget. 2015 Aug 7;6(22):18875-90. doi: 10.18632/oncotarget.4303. Oncotarget. 2015. PMID: 26056084 Free PMC article.
51 results