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Estrogen inhibits transforming growth factor beta signaling by promoting Smad2/3 degradation.
Ito I, Hanyu A, Wayama M, Goto N, Katsuno Y, Kawasaki S, Nakajima Y, Kajiro M, Komatsu Y, Fujimura A, Hirota R, Murayama A, Kimura K, Imamura T, Yanagisawa J. Ito I, et al. Among authors: imamura t. J Biol Chem. 2010 May 7;285(19):14747-55. doi: 10.1074/jbc.M109.093039. Epub 2010 Mar 5. J Biol Chem. 2010. PMID: 20207742 Free PMC article.
Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7.
Tajima Y, Goto K, Yoshida M, Shinomiya K, Sekimoto T, Yoneda Y, Miyazono K, Imamura T. Tajima Y, et al. Among authors: imamura t. J Biol Chem. 2003 Mar 21;278(12):10716-21. doi: 10.1074/jbc.M212663200. Epub 2003 Jan 7. J Biol Chem. 2003. PMID: 12519765 Free article.
NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.
Kuratomi G, Komuro A, Goto K, Shinozaki M, Miyazawa K, Miyazono K, Imamura T. Kuratomi G, et al. Among authors: imamura t. Biochem J. 2005 Mar 15;386(Pt 3):461-70. doi: 10.1042/BJ20040738. Biochem J. 2005. PMID: 15496141 Free PMC article.
2,887 results