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New molecular targets for the treatment of osteoarthritis.
Biochem Pharmacol. 2010 Jul 1;80(1):13-21. doi: 10.1016/j.bcp.2010.02.017. Epub 2010 Mar 3.
Biochem Pharmacol. 2010.
PMID: 20206140
Review.
Heme oxygenase-1 induction modulates microsomal prostaglandin E synthase-1 expression and prostaglandin E(2) production in osteoarthritic chondrocytes.
Megías J, Guillén MI, Clérigues V, Rojo AI, Cuadrado A, Castejón MA, Gomar F, Alcaraz MJ.
Megías J, et al. Among authors: clerigues v.
Biochem Pharmacol. 2009 Jun 15;77(12):1806-13. doi: 10.1016/j.bcp.2009.03.009. Epub 2009 Mar 21.
Biochem Pharmacol. 2009.
PMID: 19428335
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Heme oxygenase-1 mediates protective effects on inflammatory, catabolic and senescence responses induced by interleukin-1β in osteoarthritic osteoblasts.
Clérigues V, Guillén MI, Castejón MA, Gomar F, Mirabet V, Alcaraz MJ.
Clérigues V, et al.
Biochem Pharmacol. 2012 Feb 1;83(3):395-405. doi: 10.1016/j.bcp.2011.11.024. Epub 2011 Dec 2.
Biochem Pharmacol. 2012.
PMID: 22155307
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Haem oxygenase-1 counteracts the effects of interleukin-1β on inflammatory and senescence markers in cartilage-subchondral bone explants from osteoarthritic patients.
Clérigues V, Guillén MI, Gomar F, Alcaraz MJ.
Clérigues V, et al.
Clin Sci (Lond). 2012 Mar;122(5):239-50. doi: 10.1042/CS20100519.
Clin Sci (Lond). 2012.
PMID: 21954917
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Haem oxygenase-1 induction reverses the actions of interleukin-1β on hypoxia-inducible transcription factors and human chondrocyte metabolism in hypoxia.
Clérigues V, Murphy CL, Guillén MI, Alcaraz MJ.
Clérigues V, et al.
Clin Sci (Lond). 2013 Jul 1;125(2):99-108. doi: 10.1042/CS20120491.
Clin Sci (Lond). 2013.
PMID: 23406266
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The CO-releasing molecule CORM-2 is a novel regulator of the inflammatory process in osteoarthritic chondrocytes.
Guillén MI, Megías J, Clérigues V, Gomar F, Alcaraz MJ.
Guillén MI, et al. Among authors: clerigues v.
Rheumatology (Oxford). 2008 Sep;47(9):1323-8. doi: 10.1093/rheumatology/ken264. Epub 2008 Jul 11.
Rheumatology (Oxford). 2008.
PMID: 18621749
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