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Simultaneous targeting of Aurora kinases and Bcr-Abl kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I.
Gontarewicz A, Balabanov S, Keller G, Colombo R, Graziano A, Pesenti E, Benten D, Bokemeyer C, Fiedler W, Moll J, Brümmendorf TH. Gontarewicz A, et al. Among authors: colombo r. Blood. 2008 Apr 15;111(8):4355-64. doi: 10.1182/blood-2007-09-113175. Epub 2008 Feb 11. Blood. 2008. PMID: 18268096 Free article.
Targeting aneuploid cancer cells.
Colombo R, Moll J. Colombo R, et al. Expert Opin Ther Targets. 2011 May;15(5):595-608. doi: 10.1517/14728222.2011.558007. Epub 2011 Feb 12. Expert Opin Ther Targets. 2011. PMID: 21314491 Review.
1,061 results