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P66Shc signals to age.
Trinei M, Berniakovich I, Beltrami E, Migliaccio E, Fassina A, Pelicci P, Giorgio M. Trinei M, et al. Aging (Albany NY). 2009 Jun 5;1(6):503-10. doi: 10.18632/aging.100057. Aging (Albany NY). 2009. PMID: 20157533 Free PMC article. Review.
p66Shc-generated oxidative signal promotes fat accumulation.
Berniakovich I, Trinei M, Stendardo M, Migliaccio E, Minucci S, Bernardi P, Pelicci PG, Giorgio M. Berniakovich I, et al. Among authors: trinei m. J Biol Chem. 2008 Dec 5;283(49):34283-93. doi: 10.1074/jbc.M804362200. Epub 2008 Oct 6. J Biol Chem. 2008. PMID: 18838380 Free PMC article.
The p66Shc knocked out mice are short lived under natural condition.
Giorgio M, Berry A, Berniakovich I, Poletaeva I, Trinei M, Stendardo M, Hagopian K, Ramsey JJ, Cortopassi G, Migliaccio E, Nötzli S, Amrein I, Lipp HP, Cirulli F, Pelicci PG. Giorgio M, et al. Among authors: trinei m. Aging Cell. 2012 Feb;11(1):162-8. doi: 10.1111/j.1474-9726.2011.00770.x. Epub 2011 Dec 28. Aging Cell. 2012. PMID: 22081964 Free article.
The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.
Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, Martin-Padura I, Pelliccia G, Trinei M, Bono M, Puri C, Tacchetti C, Ferrini M, Mannucci R, Nicoletti I, Lanfrancone L, Giorgio M, Pelicci PG. Orsini F, et al. Among authors: trinei m. J Biol Chem. 2004 Jun 11;279(24):25689-95. doi: 10.1074/jbc.M401844200. Epub 2004 Apr 12. J Biol Chem. 2004. PMID: 15078873 Free article.
29 results