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Renal cells activate the platelet receptor CLEC-2 through podoplanin.
Christou CM, Pearce AC, Watson AA, Mistry AR, Pollitt AY, Fenton-May AE, Johnson LA, Jackson DG, Watson SP, O'Callaghan CA. Christou CM, et al. Among authors: pollitt ay. Biochem J. 2008 Apr 1;411(1):133-40. doi: 10.1042/BJ20071216. Biochem J. 2008. PMID: 18215137 Free PMC article.
CLEC-2 activates Syk through dimerization.
Hughes CE, Pollitt AY, Mori J, Eble JA, Tomlinson MG, Hartwig JH, O'Callaghan CA, Fütterer K, Watson SP. Hughes CE, et al. Among authors: pollitt ay. Blood. 2010 Apr 8;115(14):2947-55. doi: 10.1182/blood-2009-08-237834. Epub 2010 Feb 12. Blood. 2010. PMID: 20154219 Free PMC article.
GPVI and CLEC-2 in hemostasis and vascular integrity.
Watson SP, Herbert JM, Pollitt AY. Watson SP, et al. Among authors: pollitt ay. J Thromb Haemost. 2010 Jul;8(7):1456-67. doi: 10.1111/j.1538-7836.2010.03875.x. Epub 2010 Mar 25. J Thromb Haemost. 2010. PMID: 20345705 Free article. Review.
CLEC-2 is not required for platelet aggregation at arteriolar shear.
Hughes CE, Navarro-Núñez L, Finney BA, Mourão-Sá D, Pollitt AY, Watson SP. Hughes CE, et al. Among authors: pollitt ay. J Thromb Haemost. 2010 Oct;8(10):2328-2332. doi: 10.1111/j.1538-7836.2010.04006.x. J Thromb Haemost. 2010. PMID: 20695981 Free PMC article. No abstract available.
CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.
Finney BA, Schweighoffer E, Navarro-Núñez L, Bénézech C, Barone F, Hughes CE, Langan SA, Lowe KL, Pollitt AY, Mourao-Sa D, Sheardown S, Nash GB, Smithers N, Reis e Sousa C, Tybulewicz VL, Watson SP. Finney BA, et al. Among authors: pollitt ay. Blood. 2012 Feb 16;119(7):1747-56. doi: 10.1182/blood-2011-09-380709. Epub 2011 Dec 20. Blood. 2012. PMID: 22186994 Free PMC article.
35 results