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Synthesis of 3,4,5-trisubstituted-1,2,4-triazoles.
Moulin A, Bibian M, Blayo AL, El Habnouni S, Martinez J, Fehrentz JA. Moulin A, et al. Among authors: blayo al. Chem Rev. 2010 Apr 14;110(4):1809-27. doi: 10.1021/cr900107r. Chem Rev. 2010. PMID: 20151658 Review. No abstract available.
New trisubstituted 1,2,4-triazoles as ghrelin receptor antagonists.
Blayo AL, Maingot M, Aicher B, M'Kadmi C, Schmidt P, Müller G, Teifel M, Günther E, Gagne D, Denoyelle S, Martinez J, Fehrentz JA. Blayo AL, et al. Bioorg Med Chem Lett. 2015 Jan 1;25(1):20-4. doi: 10.1016/j.bmcl.2014.11.031. Epub 2014 Nov 15. Bioorg Med Chem Lett. 2015. PMID: 25435152
Triazole GHS-R1a antagonists JMV4208 and JMV3002 attenuate food intake, body weight, and adipose tissue mass in mice.
Holubová M, Nagelová V, Lacinová Z, Haluzík M, Sýkora D, Moulin A, Blayo AL, Fehrentz JA, Martinez J, Stofkova A, Jurčovičová J, Zelezná B, Maletínská L. Holubová M, et al. Among authors: blayo al. Mol Cell Endocrinol. 2014 Aug 5;393(1-2):120-8. doi: 10.1016/j.mce.2014.06.003. Epub 2014 Jun 20. Mol Cell Endocrinol. 2014. PMID: 24953973
New ligands of the ghrelin receptor based on the 1,2,4-triazole scaffold by introduction of a second chiral center.
Maingot M, Blayo AL, Denoyelle S, M'Kadmi C, Damian M, Mary S, Gagne D, Sanchez P, Aicher B, Schmidt P, Müller G, Teifel M, Günther E, Marie J, Banères JL, Martinez J, Fehrentz JA. Maingot M, et al. Among authors: blayo al. Bioorg Med Chem Lett. 2016 May 15;26(10):2408-2412. doi: 10.1016/j.bmcl.2016.04.003. Epub 2016 Apr 4. Bioorg Med Chem Lett. 2016. PMID: 27072910
Development of Nonpeptidic Inverse Agonists of the Ghrelin Receptor (GHSR) Based on the 1,2,4-Triazole Scaffold.
Haj Salah KB, Maingot M, Blayo AL, M'Kadmi C, Damian M, Mary S, Cantel S, Neasta J, Oiry C, Péraldi-Roux S, Fernandez G, Romero GG, Perello M, Marie J, Banères JL, Fehrentz JA, Denoyelle S. Haj Salah KB, et al. Among authors: blayo al. J Med Chem. 2020 Oct 8;63(19):10796-10815. doi: 10.1021/acs.jmedchem.9b02122. Epub 2020 Sep 21. J Med Chem. 2020. PMID: 32882134
Design, Synthesis, and Biological Evaluation of Indole Biphenylcarboxylic Acids as PPARγ Antagonists.
Asteian A, Blayo AL, He Y, Koenig M, Shin Y, Kuruvilla DS, Corzo CA, Cameron MD, Lin L, Ruiz C, Khan S, Kumar N, Busby S, Marciano DP, Garcia-Ordonez RD, Griffin PR, Kamenecka TM. Asteian A, et al. Among authors: blayo al. ACS Med Chem Lett. 2015 Aug 4;6(9):998-1003. doi: 10.1021/acsmedchemlett.5b00218. eCollection 2015 Sep 10. ACS Med Chem Lett. 2015. PMID: 26396687 Free PMC article.
A structural mechanism for directing corepressor-selective inverse agonism of PPARγ.
Brust R, Shang J, Fuhrmann J, Mosure SA, Bass J, Cano A, Heidari Z, Chrisman IM, Nemetchek MD, Blayo AL, Griffin PR, Kamenecka TM, Hughes TS, Kojetin DJ. Brust R, et al. Among authors: blayo al. Nat Commun. 2018 Nov 8;9(1):4687. doi: 10.1038/s41467-018-07133-w. Nat Commun. 2018. PMID: 30409975 Free PMC article.
An alternate binding site for PPARγ ligands.
Hughes TS, Giri PK, de Vera IM, Marciano DP, Kuruvilla DS, Shin Y, Blayo AL, Kamenecka TM, Burris TP, Griffin PR, Kojetin DJ. Hughes TS, et al. Among authors: blayo al. Nat Commun. 2014 Apr 7;5:3571. doi: 10.1038/ncomms4571. Nat Commun. 2014. PMID: 24705063 Free PMC article.
13 results