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Macrophages, inflammation, and insulin resistance.
Olefsky JM, Glass CK. Olefsky JM, et al. Annu Rev Physiol. 2010;72:219-46. doi: 10.1146/annurev-physiol-021909-135846. Annu Rev Physiol. 2010. PMID: 20148674 Review.
Muscle-specific Pparg deletion causes insulin resistance.
Hevener AL, He W, Barak Y, Le J, Bandyopadhyay G, Olson P, Wilkes J, Evans RM, Olefsky J. Hevener AL, et al. Nat Med. 2003 Dec;9(12):1491-7. doi: 10.1038/nm956. Epub 2003 Nov 16. Nat Med. 2003. PMID: 14625542
IKK-beta links inflammation to obesity-induced insulin resistance.
Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M. Arkan MC, et al. Among authors: olefsky j. Nat Med. 2005 Feb;11(2):191-8. doi: 10.1038/nm1185. Epub 2005 Jan 30. Nat Med. 2005. PMID: 15685170
Inflamed fat: what starts the fire?
Neels JG, Olefsky JM. Neels JG, et al. Among authors: olefsky jm. J Clin Invest. 2006 Jan;116(1):33-5. doi: 10.1172/JCI27280. J Clin Invest. 2006. PMID: 16395402 Free PMC article.
Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones.
Hevener AL, Olefsky JM, Reichart D, Nguyen MT, Bandyopadyhay G, Leung HY, Watt MJ, Benner C, Febbraio MA, Nguyen AK, Folian B, Subramaniam S, Gonzalez FJ, Glass CK, Ricote M. Hevener AL, et al. Among authors: olefsky jm. J Clin Invest. 2007 Jun;117(6):1658-69. doi: 10.1172/JCI31561. Epub 2007 May 24. J Clin Invest. 2007. PMID: 17525798 Free PMC article.
A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways.
Nguyen MT, Favelyukis S, Nguyen AK, Reichart D, Scott PA, Jenn A, Liu-Bryan R, Glass CK, Neels JG, Olefsky JM. Nguyen MT, et al. Among authors: olefsky jm. J Biol Chem. 2007 Nov 30;282(48):35279-92. doi: 10.1074/jbc.M706762200. Epub 2007 Oct 4. J Biol Chem. 2007. PMID: 17916553 Free article.
543 results