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NisT, the transporter of the lantibiotic nisin, can transport fully modified, dehydrated, and unmodified prenisin and fusions of the leader peptide with non-lantibiotic peptides.
Kuipers A, de Boef E, Rink R, Fekken S, Kluskens LD, Driessen AJ, Leenhouts K, Kuipers OP, Moll GN. Kuipers A, et al. Among authors: rink r. J Biol Chem. 2004 May 21;279(21):22176-82. doi: 10.1074/jbc.M312789200. Epub 2004 Mar 24. J Biol Chem. 2004. PMID: 15044440 Free article.
To protect peptide pharmaceuticals against peptidases.
Rink R, Arkema-Meter A, Baudoin I, Post E, Kuipers A, Nelemans SA, Akanbi MH, Moll GN. Rink R, et al. J Pharmacol Toxicol Methods. 2010 Mar-Apr;61(2):210-8. doi: 10.1016/j.vascn.2010.02.010. Epub 2010 Feb 20. J Pharmacol Toxicol Methods. 2010. PMID: 20176117
316 results