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Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs.
Coughlin JE, Padmanabhan S, Zhang G, Kirk CJ, Govardhan CP, Korba BE, O'Loughlin K, Green CE, Mirsalis J, Morrey JD, Iyer RP. Coughlin JE, et al. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1783-6. doi: 10.1016/j.bmcl.2010.01.010. Epub 2010 Jan 11. Bioorg Med Chem Lett. 2010. PMID: 20117930 Free PMC article.
Pharmacokinetics and Metabolism of 4R-Cembranoid.
Vélez-Carrasco W, Green CE, Catz P, Furimsky A, O'Loughlin K, Eterović VA, Ferchmin PA. Vélez-Carrasco W, et al. PLoS One. 2015 Mar 26;10(3):e0121540. doi: 10.1371/journal.pone.0121540. eCollection 2015. PLoS One. 2015. PMID: 25811857 Free PMC article.
Evaluation of the Activity of Lamivudine and Zidovudine against Ebola Virus.
Cong Y, Dyall J, Hart BJ, DeWald LE, Johnson JC, Postnikova E, Zhou H, Gross R, Rojas O, Alexander I, Josleyn N, Zhang T, Michelotti J, Janosko K, Glass PJ, Flint M, McMullan LK, Spiropoulou CF, Mierzwa T, Guha R, Shinn P, Michael S, Klumpp-Thomas C, McKnight C, Thomas C, Eakin AE, O'Loughlin KG, Green CE, Catz P, Mirsalis JC, Honko AN, Olinger GG Jr, Bennett RS, Holbrook MR, Hensley LE, Jahrling PB. Cong Y, et al. PLoS One. 2016 Nov 30;11(11):e0166318. doi: 10.1371/journal.pone.0166318. eCollection 2016. PLoS One. 2016. PMID: 27902714 Free PMC article.
Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection.
Ekins S, Lingerfelt MA, Comer JE, Freiberg AN, Mirsalis JC, O'Loughlin K, Harutyunyan A, McFarlane C, Green CE, Madrid PB. Ekins S, et al. Antimicrob Agents Chemother. 2018 Jan 25;62(2):e01711-17. doi: 10.1128/AAC.01711-17. Print 2018 Feb. Antimicrob Agents Chemother. 2018. PMID: 29133569 Free PMC article.
Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120.
Curreli F, Belov DS, Kwon YD, Ramesh R, Furimsky AM, O'Loughlin K, Byrge PC, Iyer LV, Mirsalis JC, Kurkin AV, Altieri A, Debnath AK. Curreli F, et al. Eur J Med Chem. 2018 Jun 25;154:367-391. doi: 10.1016/j.ejmech.2018.04.062. Epub 2018 May 12. Eur J Med Chem. 2018. PMID: 29860061 Free PMC article.
In Vitro and In Vivo Activity of Amiodarone Against Ebola Virus.
Dyall J, Johnson JC, Hart BJ, Postnikova E, Cong Y, Zhou H, Gerhardt DM, Michelotti J, Honko AN, Kern S, DeWald LE, O'Loughlin KG, Green CE, Mirsalis JC, Bennett RS, Olinger GG Jr, Jahrling PB, Hensley LE. Dyall J, et al. J Infect Dis. 2018 Nov 22;218(suppl_5):S592-S596. doi: 10.1093/infdis/jiy345. J Infect Dis. 2018. PMID: 30016444 Free PMC article.
140 results