Wirth B - Search Results

1

Neuromuscular defects and breathing disorders in a new mouse model of spinal muscular atrophy.

Michaud M, Arnoux T, Bielli S, Durand E, Rotrou Y, Jablonka S, Robert F, Giraudon-Paoli M, Riessland M, Mattei MG, Andriambeloson E, Wirth B, Sendtner M, Gallego J, Pruss RM, Bordet T. Michaud M, et al. Among authors: wirth b. Neurobiol Dis. 2010 Apr;38(1):125-35. doi: 10.1016/j.nbd.2010.01.006. Epub 2010 Jan 18. Neurobiol Dis. 2010. PMID: 20085811

2

Co-regulation of survival of motor neuron (SMN) protein and its interactor SIP1 during development and in spinal muscular atrophy.

Jablonka S, Bandilla M, Wiese S, Bühler D, Wirth B, Sendtner M, Fischer U. Jablonka S, et al. Among authors: wirth b. Hum Mol Genet. 2001 Mar 1;10(5):497-505. doi: 10.1093/hmg/10.5.497. Hum Mol Genet. 2001. PMID: 11181573

3

The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells.

Riessland M, Brichta L, Hahnen E, Wirth B. Riessland M, et al. Among authors: wirth b. Hum Genet. 2006 Aug;120(1):101-10. doi: 10.1007/s00439-006-0186-1. Epub 2006 May 25. Hum Genet. 2006. PMID: 16724231

4

In vitro and ex vivo evaluation of second-generation histone deacetylase inhibitors for the treatment of spinal muscular atrophy.

Hahnen E, Eyüpoglu IY, Brichta L, Haastert K, Tränkle C, Siebzehnrübl FA, Riessland M, Hölker I, Claus P, Romstöck J, Buslei R, Wirth B, Blümcke I. Hahnen E, et al. Among authors: wirth b. J Neurochem. 2006 Jul;98(1):193-202. doi: 10.1111/j.1471-4159.2006.03868.x. J Neurochem. 2006. PMID: 16805808 Free article.

5

Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition.

Hauke J, Riessland M, Lunke S, Eyüpoglu IY, Blümcke I, El-Osta A, Wirth B, Hahnen E. Hauke J, et al. Among authors: wirth b. Hum Mol Genet. 2009 Jan 15;18(2):304-17. doi: 10.1093/hmg/ddn357. Epub 2008 Oct 29. Hum Mol Genet. 2009. PMID: 18971205 Free PMC article.

6

LBH589 induces up to 10-fold SMN protein levels by several independent mechanisms and is effective even in cells from SMA patients non-responsive to valproate.

Garbes L, Riessland M, Hölker I, Heller R, Hauke J, Tränkle C, Coras R, Blümcke I, Hahnen E, Wirth B. Garbes L, et al. Among authors: wirth b. Hum Mol Genet. 2009 Oct 1;18(19):3645-58. doi: 10.1093/hmg/ddp313. Epub 2009 Jul 7. Hum Mol Genet. 2009. PMID: 19584083

7

SAHA ameliorates the SMA phenotype in two mouse models for spinal muscular atrophy.

Riessland M, Ackermann B, Förster A, Jakubik M, Hauke J, Garbes L, Fritzsche I, Mende Y, Blumcke I, Hahnen E, Wirth B. Riessland M, et al. Among authors: wirth b. Hum Mol Genet. 2010 Apr 15;19(8):1492-506. doi: 10.1093/hmg/ddq023. Epub 2010 Jan 22. Hum Mol Genet. 2010. PMID: 20097677

8

Deficiency of the splicing factor Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn splicing.

Mende Y, Jakubik M, Riessland M, Schoenen F, Rossbach K, Kleinridders A, Köhler C, Buch T, Wirth B. Mende Y, et al. Among authors: wirth b. Hum Mol Genet. 2010 Jun 1;19(11):2154-67. doi: 10.1093/hmg/ddq094. Epub 2010 Feb 27. Hum Mol Genet. 2010. PMID: 20190275

9

Reversible molecular pathology of skeletal muscle in spinal muscular atrophy.

Mutsaers CA, Wishart TM, Lamont DJ, Riessland M, Schreml J, Comley LH, Murray LM, Parson SH, Lochmüller H, Wirth B, Talbot K, Gillingwater TH. Mutsaers CA, et al. Among authors: wirth b. Hum Mol Genet. 2011 Nov 15;20(22):4334-44. doi: 10.1093/hmg/ddr360. Epub 2011 Aug 12. Hum Mol Genet. 2011. PMID: 21840928

10

The spinal muscular atrophy disease protein SMN is linked to the Rho-kinase pathway via profilin.

Nölle A, Zeug A, van Bergeijk J, Tönges L, Gerhard R, Brinkmann H, Al Rayes S, Hensel N, Schill Y, Apkhazava D, Jablonka S, O'mer J, Srivastav RK, Baasner A, Lingor P, Wirth B, Ponimaskin E, Niedenthal R, Grothe C, Claus P. Nölle A, et al. Among authors: wirth b. Hum Mol Genet. 2011 Dec 15;20(24):4865-78. doi: 10.1093/hmg/ddr425. Epub 2011 Sep 14. Hum Mol Genet. 2011. PMID: 21920940

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