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The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma.
Xu GW, Ali M, Wood TE, Wong D, Maclean N, Wang X, Gronda M, Skrtic M, Li X, Hurren R, Mao X, Venkatesan M, Beheshti Zavareh R, Ketela T, Reed JC, Rose D, Moffat J, Batey RA, Dhe-Paganon S, Schimmer AD. Xu GW, et al. Among authors: schimmer ad. Blood. 2010 Mar 18;115(11):2251-9. doi: 10.1182/blood-2009-07-231191. Epub 2010 Jan 14. Blood. 2010. PMID: 20075161 Free PMC article.
The triterpenoid CDDO induces apoptosis in refractory CLL B cells.
Pedersen IM, Kitada S, Schimmer A, Kim Y, Zapata JM, Charboneau L, Rassenti L, Andreeff M, Bennett F, Sporn MB, Liotta LD, Kipps TJ, Reed JC. Pedersen IM, et al. Blood. 2002 Oct 15;100(8):2965-72. doi: 10.1182/blood-2002-04-1174. Blood. 2002. PMID: 12351409 Free article.
Bcl-2 and apoptosis in chronic lymphocytic leukemia.
Schimmer AD, Munk-Pedersen I, Minden MD, Reed JC. Schimmer AD, et al. Curr Treat Options Oncol. 2003 Jun;4(3):211-8. doi: 10.1007/s11864-003-0022-y. Curr Treat Options Oncol. 2003. PMID: 12718798 Review.
Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells.
Carter BZ, Gronda M, Wang Z, Welsh K, Pinilla C, Andreeff M, Schober WD, Nefzi A, Pond GR, Mawji IA, Houghten RA, Ostresh J, Brandwein J, Minden MD, Schuh AC, Wells RA, Messner H, Chun K, Reed JC, Schimmer AD. Carter BZ, et al. Among authors: schimmer ad. Blood. 2005 May 15;105(10):4043-50. doi: 10.1182/blood-2004-08-3168. Epub 2005 Feb 1. Blood. 2005. PMID: 15687241 Free PMC article.
Targeting XIAP for the treatment of malignancy.
Schimmer AD, Dalili S, Batey RA, Riedl SJ. Schimmer AD, et al. Cell Death Differ. 2006 Feb;13(2):179-88. doi: 10.1038/sj.cdd.4401826. Cell Death Differ. 2006. PMID: 16322751 Review.
295 results