Hazuda DJ - Search Results

1

Purification of untagged HIV-1 reverse transcriptase by affinity chromatography.

Lu M, Ngo W, Mei Y, Munshi V, Burlein C, Loughran MH, Williams PD, Hazuda DJ, Miller MD, Grobler JA, Diamond TL, Lai MT. Lu M, et al. Among authors: hazuda dj. Protein Expr Purif. 2010 Jun;71(2):231-9. doi: 10.1016/j.pep.2010.01.001. Epub 2010 Jan 8. Protein Expr Purif. 2010. PMID: 20060474

2

Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells.

Hazuda DJ, Felock P, Witmer M, Wolfe A, Stillmock K, Grobler JA, Espeseth A, Gabryelski L, Schleif W, Blau C, Miller MD. Hazuda DJ, et al. Science. 2000 Jan 28;287(5453):646-50. doi: 10.1126/science.287.5453.646. Science. 2000. PMID: 10649997

3

HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase.

Espeseth AS, Felock P, Wolfe A, Witmer M, Grobler J, Anthony N, Egbertson M, Melamed JY, Young S, Hamill T, Cole JL, Hazuda DJ. Espeseth AS, et al. Among authors: hazuda dj. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11244-9. doi: 10.1073/pnas.200139397. Proc Natl Acad Sci U S A. 2000. PMID: 11016953 Free PMC article.

4

New antiretroviral agents: looking beyond protease and reverse transcriptase.

Miller MD, Hazuda DJ. Miller MD, et al. Among authors: hazuda dj. Curr Opin Microbiol. 2001 Oct;4(5):535-9. doi: 10.1016/s1369-5274(00)00247-2. Curr Opin Microbiol. 2001. PMID: 11587929 Review.

5

Potential new therapies for the treatment of HIV-1 infection.

Condra JH, Miller MD, Hazuda DJ, Emini EA. Condra JH, et al. Among authors: hazuda dj. Annu Rev Med. 2002;53:541-55. doi: 10.1146/annurev.med.53.082901.104110. Annu Rev Med. 2002. PMID: 11818489 Review.

6

Altering expression levels of human immunodeficiency virus type 1 gp120-gp41 affects efficiency but not kinetics of cell-cell fusion.

Lineberger JE, Danzeisen R, Hazuda DJ, Simon AJ, Miller MD. Lineberger JE, et al. Among authors: hazuda dj. J Virol. 2002 Apr;76(7):3522-33. doi: 10.1128/jvi.76.7.3522-3533.2002. J Virol. 2002. PMID: 11884576 Free PMC article.

7

Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes.

Grobler JA, Stillmock K, Hu B, Witmer M, Felock P, Espeseth AS, Wolfe A, Egbertson M, Bourgeois M, Melamed J, Wai JS, Young S, Vacca J, Hazuda DJ. Grobler JA, et al. Among authors: hazuda dj. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6661-6. doi: 10.1073/pnas.092056199. Epub 2002 May 7. Proc Natl Acad Sci U S A. 2002. PMID: 11997448 Free PMC article.

8

Inhibition of HIV-1 ribonuclease H by a novel diketo acid, 4-[5-(benzoylamino)thien-2-yl]-2,4-dioxobutanoic acid.

Shaw-Reid CA, Munshi V, Graham P, Wolfe A, Witmer M, Danzeisen R, Olsen DB, Carroll SS, Embrey M, Wai JS, Miller MD, Cole JL, Hazuda DJ. Shaw-Reid CA, et al. Among authors: hazuda dj. J Biol Chem. 2003 Jan 31;278(5):2777-80. doi: 10.1074/jbc.C200621200. Epub 2002 Dec 11. J Biol Chem. 2003. PMID: 12480948 Free article.

9

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities.

Lai MT, Chen E, Crouthamel MC, DiMuzio-Mower J, Xu M, Huang Q, Price E, Register RB, Shi XP, Donoviel DB, Bernstein A, Hazuda D, Gardell SJ, Li YM. Lai MT, et al. J Biol Chem. 2003 Jun 20;278(25):22475-81. doi: 10.1074/jbc.M300974200. Epub 2003 Apr 8. J Biol Chem. 2003. PMID: 12684521 Free article.

10

Rational design and synthesis of selective BACE-1 inhibitors.

Brady SF, Singh S, Crouthamel MC, Holloway MK, Coburn CA, Garsky VM, Bogusky M, Pennington MW, Vacca JP, Hazuda D, Lai MT. Brady SF, et al. Bioorg Med Chem Lett. 2004 Feb 9;14(3):601-4. doi: 10.1016/j.bmcl.2003.11.061. Bioorg Med Chem Lett. 2004. PMID: 14741251

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