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Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure.
Sankaranarayanan A, Raman G, Busch C, Schultz T, Zimin PI, Hoyer J, Köhler R, Wulff H. Sankaranarayanan A, et al. Among authors: kohler r. Mol Pharmacol. 2009 Feb;75(2):281-95. doi: 10.1124/mol.108.051425. Epub 2008 Oct 27. Mol Pharmacol. 2009. PMID: 18955585 Free PMC article.
Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension.
Brähler S, Kaistha A, Schmidt VJ, Wölfle SE, Busch C, Kaistha BP, Kacik M, Hasenau AL, Grgic I, Si H, Bond CT, Adelman JP, Wulff H, de Wit C, Hoyer J, Köhler R. Brähler S, et al. Among authors: kohler r. Circulation. 2009 May 5;119(17):2323-32. doi: 10.1161/CIRCULATIONAHA.108.846634. Epub 2009 Apr 20. Circulation. 2009. PMID: 19380617 Free article.
Preserved regulation of renal perfusion pressure by small and intermediate conductance KCa channels in hypertensive mice with or without renal failure.
Waeckel L, Bertin F, Clavreul N, Damery T, Köhler R, Paysant J, Sansilvestri-Morel P, Simonet S, Vayssettes-Courchay C, Wulff H, Verbeuren TJ, Félétou M. Waeckel L, et al. Among authors: kohler r. Pflugers Arch. 2015 Apr;467(4):817-31. doi: 10.1007/s00424-014-1542-y. Epub 2014 Jun 7. Pflugers Arch. 2015. PMID: 24903240
A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo.
Oliván-Viguera A, Valero MS, Coleman N, Brown BM, Laría C, Murillo MD, Gálvez JA, Díaz-de-Villegas MD, Wulff H, Badorrey R, Köhler R. Oliván-Viguera A, et al. Among authors: kohler r. Mol Pharmacol. 2015 Feb;87(2):338-48. doi: 10.1124/mol.114.095745. Epub 2014 Dec 2. Mol Pharmacol. 2015. PMID: 25468883 Free PMC article.
789 results