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Structure-activity relationship and mechanism of action studies of manzamine analogues for the control of neuroinflammation and cerebral infections.
Peng J, Kudrimoti S, Prasanna S, Odde S, Doerksen RJ, Pennaka HK, Choo YM, Rao KV, Tekwani BL, Madgula V, Khan SI, Wang B, Mayer AM, Jacob MR, Tu LC, Gertsch J, Hamann MT. Peng J, et al. Among authors: hamann mt. J Med Chem. 2010 Jan 14;53(1):61-76. doi: 10.1021/jm900672t. J Med Chem. 2010. PMID: 20017491 Free PMC article.
New manzamine alkaloids from an Indo-Pacific sponge. Pharmacokinetics, oral availability, and the significant activity of several manzamines against HIV-I, AIDS opportunistic infections, and inflammatory diseases.
Yousaf M, Hammond NL, Peng J, Wahyuono S, McIntosh KA, Charman WN, Mayer AM, Hamann MT. Yousaf M, et al. Among authors: hamann mt. J Med Chem. 2004 Jul 1;47(14):3512-7. doi: 10.1021/jm030475b. J Med Chem. 2004. PMID: 15214779 Free PMC article.
Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases.
Rao KV, Donia MS, Peng J, Garcia-Palomero E, Alonso D, Martinez A, Medina M, Franzblau SG, Tekwani BL, Khan SI, Wahyuono S, Willett KL, Hamann MT. Rao KV, et al. Among authors: hamann mt. J Nat Prod. 2006 Jul;69(7):1034-40. doi: 10.1021/np0601399. J Nat Prod. 2006. PMID: 16872140 Free PMC article.
2-N-Methyl modifications and SAR studies of manzamine A.
Ibrahim MA, Shilabin AG, Prasanna S, Jacob M, Khan SI, Doerksen RJ, Hamann MT. Ibrahim MA, et al. Among authors: hamann mt. Bioorg Med Chem. 2008 Jul 15;16(14):6702-6. doi: 10.1016/j.bmc.2008.05.079. Epub 2008 Jun 5. Bioorg Med Chem. 2008. PMID: 18595720 Free PMC article.
Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease.
Hamann M, Alonso D, Martín-Aparicio E, Fuertes A, Pérez-Puerto MJ, Castro A, Morales S, Navarro ML, Del Monte-Millán M, Medina M, Pennaka H, Balaiah A, Peng J, Cook J, Wahyuono S, Martínez A. Hamann M, et al. J Nat Prod. 2007 Sep;70(9):1397-405. doi: 10.1021/np060092r. Epub 2007 Aug 21. J Nat Prod. 2007. PMID: 17708655
189 results