Crosby J - Search Results

1

Phosphopantetheinylation and specificity of acyl carrier proteins in the mupirocin biosynthetic cluster.

Shields JA, Rahman AS, Arthur CJ, Crosby J, Hothersall J, Simpson TJ, Thomas CM. Shields JA, et al. Among authors: crosby j. Chembiochem. 2010 Jan 25;11(2):248-55. doi: 10.1002/cbic.200900565. Chembiochem. 2010. PMID: 20013982

2

Tandemly duplicated acyl carrier proteins, which increase polyketide antibiotic production, can apparently function either in parallel or in series.

Rahman AS, Hothersall J, Crosby J, Simpson TJ, Thomas CM. Rahman AS, et al. Among authors: crosby j. J Biol Chem. 2005 Feb 25;280(8):6399-408. doi: 10.1074/jbc.M409814200. Epub 2004 Dec 6. J Biol Chem. 2005. PMID: 15583005 Free article.

3

Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster.

Cooper SM, Cox RJ, Crosby J, Crump MP, Hothersall J, Laosripaiboon W, Simpson TJ, Thomas CM. Cooper SM, et al. Among authors: crosby j. Chem Commun (Camb). 2005 Mar 7;(9):1179-81. doi: 10.1039/b414781b. Epub 2005 Jan 17. Chem Commun (Camb). 2005. PMID: 15726184

4

Shift to Pseudomonic acid B production in P. fluorescens NCIMB10586 by mutation of mupirocin tailoring genes mupO, mupU, mupV, and macpE.

Cooper SM, Laosripaiboon W, Rahman AS, Hothersall J, El-Sayed AK, Winfield C, Crosby J, Cox RJ, Simpson TJ, Thomas CM. Cooper SM, et al. Among authors: crosby j. Chem Biol. 2005 Jul;12(7):825-33. doi: 10.1016/j.chembiol.2005.05.015. Chem Biol. 2005. PMID: 16039529

5

Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by pseudomonas fluorescens: pseudomonic acid B biosynthesis precedes pseudomonic acid A.

Hothersall J, Wu J, Rahman AS, Shields JA, Haddock J, Johnson N, Cooper SM, Stephens ER, Cox RJ, Crosby J, Willis CL, Simpson TJ, Thomas CM. Hothersall J, et al. Among authors: crosby j. J Biol Chem. 2007 May 25;282(21):15451-61. doi: 10.1074/jbc.M701490200. Epub 2007 Mar 23. J Biol Chem. 2007. PMID: 17383964 Free article.

6

In vivo mutational analysis of the mupirocin gene cluster reveals labile points in the biosynthetic pathway: the "leaky hosepipe" mechanism.

Wu J, Hothersall J, Mazzetti C, O'Connell Y, Shields JA, Rahman AS, Cox RJ, Crosby J, Simpson TJ, Thomas CM, Willis CL. Wu J, et al. Among authors: crosby j. Chembiochem. 2008 Jun 16;9(9):1500-8. doi: 10.1002/cbic.200800085. Chembiochem. 2008. PMID: 18465759

7

An ACP structural switch: conformational differences between the apo and holo forms of the actinorhodin polyketide synthase acyl carrier protein.

Evans SE, Williams C, Arthur CJ, Burston SG, Simpson TJ, Crosby J, Crump MP. Evans SE, et al. Among authors: crosby j. Chembiochem. 2008 Oct 13;9(15):2424-32. doi: 10.1002/cbic.200800180. Chembiochem. 2008. PMID: 18770515

8

Manipulation of quorum sensing regulation in Pseudomonas fluorescens NCIMB 10586 to increase mupirocin production.

Hothersall J, Murphy AC, Iqbal Z, Campbell G, Stephens ER, Wu J, Cooper H, Atkinson S, Williams P, Crosby J, Willis CL, Cox RJ, Simpson TJ, Thomas CM. Hothersall J, et al. Among authors: crosby j. Appl Microbiol Biotechnol. 2011 May;90(3):1017-26. doi: 10.1007/s00253-011-3145-2. Epub 2011 Feb 12. Appl Microbiol Biotechnol. 2011. PMID: 21318358

9

A natural plasmid uniquely encodes two biosynthetic pathways creating a potent anti-MRSA antibiotic.

Fukuda D, Haines AS, Song Z, Murphy AC, Hothersall J, Stephens ER, Gurney R, Cox RJ, Crosby J, Willis CL, Simpson TJ, Thomas CM. Fukuda D, et al. Among authors: crosby j. PLoS One. 2011 Mar 31;6(3):e18031. doi: 10.1371/journal.pone.0018031. PLoS One. 2011. PMID: 21483852 Free PMC article.

10

A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis.

Haines AS, Dong X, Song Z, Farmer R, Williams C, Hothersall J, Płoskoń E, Wattana-Amorn P, Stephens ER, Yamada E, Gurney R, Takebayashi Y, Masschelein J, Cox RJ, Lavigne R, Willis CL, Simpson TJ, Crosby J, Winn PJ, Thomas CM, Crump MP. Haines AS, et al. Among authors: crosby j. Nat Chem Biol. 2013 Nov;9(11):685-692. doi: 10.1038/nchembio.1342. Epub 2013 Sep 22. Nat Chem Biol. 2013. PMID: 24056399 Free PMC article.

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