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Awakening guardian angels: drugging the p53 pathway.
Brown CJ, Lain S, Verma CS, Fersht AR, Lane DP. Brown CJ, et al. Among authors: fersht ar. Nat Rev Cancer. 2009 Dec;9(12):862-73. doi: 10.1038/nrc2763. Nat Rev Cancer. 2009. PMID: 19935675 Review.
Thermodynamic stability of wild-type and mutant p53 core domain.
Bullock AN, Henckel J, DeDecker BS, Johnson CM, Nikolova PV, Proctor MR, Lane DP, Fersht AR. Bullock AN, et al. Among authors: fersht ar. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14338-42. doi: 10.1073/pnas.94.26.14338. Proc Natl Acad Sci U S A. 1997. PMID: 9405613 Free PMC article.
Rescuing the function of mutant p53.
Bullock AN, Fersht AR. Bullock AN, et al. Among authors: fersht ar. Nat Rev Cancer. 2001 Oct;1(1):68-76. doi: 10.1038/35094077. Nat Rev Cancer. 2001. PMID: 11900253 Review.
PRIMA-1 reactivates mutant p53 by covalent binding to the core domain.
Lambert JM, Gorzov P, Veprintsev DB, Söderqvist M, Segerbäck D, Bergman J, Fersht AR, Hainaut P, Wiman KG, Bykov VJ. Lambert JM, et al. Among authors: fersht ar. Cancer Cell. 2009 May 5;15(5):376-88. doi: 10.1016/j.ccr.2009.03.003. Cancer Cell. 2009. PMID: 19411067 Free article.
The tumor suppressor p53: from structures to drug discovery.
Joerger AC, Fersht AR. Joerger AC, et al. Among authors: fersht ar. Cold Spring Harb Perspect Biol. 2010 Jun;2(6):a000919. doi: 10.1101/cshperspect.a000919. Epub 2010 Feb 10. Cold Spring Harb Perspect Biol. 2010. PMID: 20516128 Free PMC article. Review.
Structural biology of the tumor suppressor p53.
Joerger AC, Fersht AR. Joerger AC, et al. Among authors: fersht ar. Annu Rev Biochem. 2008;77:557-82. doi: 10.1146/annurev.biochem.77.060806.091238. Annu Rev Biochem. 2008. PMID: 18410249 Review.
536 results