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Page 1
Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.
Angibaud P, Van Emelen K, Decrane L, van Brandt S, Ten Holte P, Pilatte I, Roux B, Poncelet V, Speybrouck D, Queguiner L, Gaurrand S, Mariën A, Floren W, Janssen L, Verdonck M, van Dun J, van Gompel J, Gilissen R, Mackie C, Du Jardin M, Peeters J, Noppe M, Van Hijfte L, Freyne E, Page M, Janicot M, Arts J. Angibaud P, et al. Among authors: ten holte p. Bioorg Med Chem Lett. 2010 Jan 1;20(1):294-8. doi: 10.1016/j.bmcl.2009.10.118. Epub 2009 Oct 30. Bioorg Med Chem Lett. 2010. PMID: 19906529
Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors.
Angibaud P, Arts J, Van Emelen K, Poncelet V, Pilatte I, Roux B, Van Brandt S, Verdonck M, De Winter H, Ten Holte P, Marien A, Floren W, Janssens B, Van Dun J, Aerts A, Van Gompel J, Gaurrand S, Queguiner L, Argoullon JM, Van Hijfte L, Freyne E, Janicot M. Angibaud P, et al. Among authors: ten holte p. Eur J Med Chem. 2005 Jun;40(6):597-606. doi: 10.1016/j.ejmech.2005.01.008. Epub 2005 Mar 3. Eur J Med Chem. 2005. PMID: 15922843
Synthesis of 3-amino-4-fluoropyrazoles.
Surmont R, Verniest G, De Schrijver M, Thuring JW, ten Holte P, Deroose F, De Kimpe N. Surmont R, et al. Among authors: ten holte p. J Org Chem. 2011 May 20;76(10):4105-11. doi: 10.1021/jo2000989. Epub 2011 Apr 29. J Org Chem. 2011. PMID: 21500813
Library enhancement through the wisdom of crowds.
Hack MD, Rassokhin DN, Buyck C, Seierstad M, Skalkin A, ten Holte P, Jones TK, Mirzadegan T, Agrafiotis DK. Hack MD, et al. Among authors: ten holte p. J Chem Inf Model. 2011 Dec 27;51(12):3275-86. doi: 10.1021/ci200446y. Epub 2011 Nov 14. J Chem Inf Model. 2011. PMID: 22035213
Synthesis of 5-amino- and 5-hydroxy-3,3-difluoropiperidines.
Surmont R, Verniest G, Thuring JW, Ten Holte P, Deroose F, De Kimpe N. Surmont R, et al. Among authors: ten holte p. Org Biomol Chem. 2010 Oct 21;8(20):4514-7. doi: 10.1039/c0ob00231c. Epub 2010 Jul 29. Org Biomol Chem. 2010. PMID: 20668779