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JNJ-26481585, a novel "second-generation" oral histone deacetylase inhibitor, shows broad-spectrum preclinical antitumoral activity.
Clin Cancer Res. 2009 Nov 15;15(22):6841-51. doi: 10.1158/1078-0432.CCR-09-0547. Epub 2009 Oct 27.
Clin Cancer Res. 2009.
PMID: 19861438
Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors.
Angibaud P, Arts J, Van Emelen K, Poncelet V, Pilatte I, Roux B, Van Brandt S, Verdonck M, De Winter H, Ten Holte P, Marien A, Floren W, Janssens B, Van Dun J, Aerts A, Van Gompel J, Gaurrand S, Queguiner L, Argoullon JM, Van Hijfte L, Freyne E, Janicot M.
Angibaud P, et al. Among authors: floren w.
Eur J Med Chem. 2005 Jun;40(6):597-606. doi: 10.1016/j.ejmech.2005.01.008. Epub 2005 Mar 3.
Eur J Med Chem. 2005.
PMID: 15922843
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Real-time gene expression analysis in human xenografts for evaluation of histone deacetylase inhibitors.
Beliën A, De Schepper S, Floren W, Janssens B, Mariën A, King P, Van Dun J, Andries L, Voeten J, Bijnens L, Janicot M, Arts J.
Beliën A, et al. Among authors: floren w.
Mol Cancer Ther. 2006 Sep;5(9):2317-23. doi: 10.1158/1535-7163.MCT-06-0112.
Mol Cancer Ther. 2006.
PMID: 16985066
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Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.
Angibaud P, Van Emelen K, Decrane L, van Brandt S, Ten Holte P, Pilatte I, Roux B, Poncelet V, Speybrouck D, Queguiner L, Gaurrand S, Mariën A, Floren W, Janssen L, Verdonck M, van Dun J, van Gompel J, Gilissen R, Mackie C, Du Jardin M, Peeters J, Noppe M, Van Hijfte L, Freyne E, Page M, Janicot M, Arts J.
Angibaud P, et al. Among authors: floren w.
Bioorg Med Chem Lett. 2010 Jan 1;20(1):294-8. doi: 10.1016/j.bmcl.2009.10.118. Epub 2009 Oct 30.
Bioorg Med Chem Lett. 2010.
PMID: 19906529
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R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies.
Arts J, Angibaud P, Mariën A, Floren W, Janssens B, King P, van Dun J, Janssen L, Geerts T, Tuman RW, Johnson DL, Andries L, Jung M, Janicot M, van Emelen K.
Arts J, et al. Among authors: floren w.
Br J Cancer. 2007 Nov 19;97(10):1344-53. doi: 10.1038/sj.bjc.6604025. Epub 2007 Nov 13.
Br J Cancer. 2007.
PMID: 18000499
Free PMC article.
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Inhibition of all-TRANS-retinoic acid metabolism by R116010 induces antitumour activity.
Van Heusden J, Van Ginckel R, Bruwiere H, Moelans P, Janssen B, Floren W, van der Leede BJ, van Dun J, Sanz G, Venet M, Dillen L, Van Hove C, Willemsens G, Janicot M, Wouters W.
Van Heusden J, et al. Among authors: floren w.
Br J Cancer. 2002 Feb 12;86(4):605-11. doi: 10.1038/sj.bjc.6600056.
Br J Cancer. 2002.
PMID: 11870544
Free PMC article.
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Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles.
Pun SH, Tack F, Bellocq NC, Cheng J, Grubbs BH, Jensen GS, Davis ME, Brewster M, Janicot M, Janssens B, Floren W, Bakker A.
Pun SH, et al. Among authors: floren w.
Cancer Biol Ther. 2004 Jul;3(7):641-50. doi: 10.4161/cbt.3.7.918. Epub 2004 Jul 9.
Cancer Biol Ther. 2004.
PMID: 15136766
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Is the forming of neuronal network activity in human-induced pluripotent stem cells important for the detection of drug-induced seizure risks?
Kreir M, Floren W, Policarpo R, De Bondt A, Van den Wyngaert I, Teisman A, Gallacher DJ, Lu HR.
Kreir M, et al. Among authors: floren w.
Eur J Pharmacol. 2022 Sep 15;931:175189. doi: 10.1016/j.ejphar.2022.175189. Epub 2022 Aug 18.
Eur J Pharmacol. 2022.
PMID: 35987255
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