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Senescence-associated oxidative DNA damage promotes the generation of neoplastic cells.
Gosselin K, Martien S, Pourtier A, Vercamer C, Ostoich P, Morat L, Sabatier L, Duprez L, T'kint de Roodenbeke C, Gilson E, Malaquin N, Wernert N, Slijepcevic P, Ashtari M, Chelli F, Deruy E, Vandenbunder B, De Launoit Y, Abbadie C. Gosselin K, et al. Among authors: de launoit y. Cancer Res. 2009 Oct 15;69(20):7917-25. doi: 10.1158/0008-5472.CAN-08-2510. Epub 2009 Oct 13. Cancer Res. 2009. PMID: 19826058
A genetic screen identifies topoisomerase 1 as a regulator of senescence.
Humbert N, Martien S, Augert A, Da Costa M, Mauen S, Abbadie C, de Launoit Y, Gil J, Bernard D. Humbert N, et al. Among authors: de launoit y. Cancer Res. 2009 May 15;69(10):4101-6. doi: 10.1158/0008-5472.CAN-08-2864. Epub 2009 May 12. Cancer Res. 2009. PMID: 19435923
Senescent keratinocytes die by autophagic programmed cell death.
Gosselin K, Deruy E, Martien S, Vercamer C, Bouali F, Dujardin T, Slomianny C, Houel-Renault L, Chelli F, De Launoit Y, Abbadie C. Gosselin K, et al. Among authors: de launoit y. Am J Pathol. 2009 Feb;174(2):423-35. doi: 10.2353/ajpath.2009.080332. Epub 2009 Jan 15. Am J Pathol. 2009. PMID: 19147823 Free PMC article.
Regulation of ploidy and senescence by the AMPK-related kinase NUAK1.
Humbert N, Navaratnam N, Augert A, Da Costa M, Martien S, Wang J, Martinez D, Abbadie C, Carling D, de Launoit Y, Gil J, Bernard D. Humbert N, et al. Among authors: de launoit y. EMBO J. 2010 Jan 20;29(2):376-86. doi: 10.1038/emboj.2009.342. Epub 2009 Nov 19. EMBO J. 2010. PMID: 19927127 Free PMC article.
PLA2R1 mediates tumor suppression by activating JAK2.
Vindrieux D, Augert A, Girard CA, Gitenay D, Lallet-Daher H, Wiel C, Le Calvé B, Gras B, Ferrand M, Verbeke S, de Launoit Y, Leroy X, Puisieux A, Aubert S, Perrais M, Gelb M, Simonnet H, Lambeau G, Bernard D. Vindrieux D, et al. Among authors: de launoit y. Cancer Res. 2013 Oct 15;73(20):6334-45. doi: 10.1158/0008-5472.CAN-13-0318. Epub 2013 Sep 5. Cancer Res. 2013. PMID: 24008317
PLA2R1 kills cancer cells by inducing mitochondrial stress.
Augert A, Vindrieux D, Girard CA, Le Calvé B, Gras B, Ferrand M, Bouchet BP, Puisieux A, de Launoit Y, Simonnet H, Lambeau G, Bernard D. Augert A, et al. Among authors: de launoit y. Free Radic Biol Med. 2013 Dec;65:969-977. doi: 10.1016/j.freeradbiomed.2013.08.177. Epub 2013 Aug 29. Free Radic Biol Med. 2013. PMID: 23994771
Autocrine induction of invasive and metastatic phenotypes by the MIF-CXCR4 axis in drug-resistant human colon cancer cells.
Dessein AF, Stechly L, Jonckheere N, Dumont P, Monté D, Leteurtre E, Truant S, Pruvot FR, Figeac M, Hebbar M, Lecellier CH, Lesuffleur T, Dessein R, Grard G, Dejonghe MJ, de Launoit Y, Furuichi Y, Prévost G, Porchet N, Gespach C, Huet G. Dessein AF, et al. Among authors: de launoit y. Cancer Res. 2010 Jun 1;70(11):4644-54. doi: 10.1158/0008-5472.CAN-09-3828. Epub 2010 May 11. Cancer Res. 2010. PMID: 20460542
165 results