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Rapid access towards follow-up NOP receptor agonists using a knowledge based approach.
Palin R, Clark JK, Evans L, Feilden H, Fletcher D, Hamilton NM, Houghton AK, Jones PS, McArthur D, Montgomery B, Ratcliffe PD, Smith AR, Sutherland A, Weston MA, Wishart G. Palin R, et al. Among authors: houghton ak. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6441-6. doi: 10.1016/j.bmcl.2009.09.028. Epub 2009 Sep 12. Bioorg Med Chem Lett. 2009. PMID: 19818611
Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists.
Palin R, Barn DR, Clark JK, Cottney JE, Cowley PM, Crockatt M, Evans L, Feilden H, Goodwin RR, Griekspoor F, Grove SJ, Houghton AK, Jones PS, Morphy RJ, Smith AR, Sundaram H, Vrolijk D, Weston MA, Wishart G, Wren P. Palin R, et al. Among authors: houghton ak. Bioorg Med Chem Lett. 2005 Feb 1;15(3):589-93. doi: 10.1016/j.bmcl.2004.11.049. Bioorg Med Chem Lett. 2005. PMID: 15664818
Design, synthesis, and structure-activity relationship study of bicyclic piperazine analogs of indole-3-carboxamides as novel cannabinoid CB1 receptor agonists.
Moir EM, Yoshiizumi K, Cairns J, Cowley P, Ferguson M, Jeremiah F, Kiyoi T, Morphy R, Tierney J, Wishart G, York M, Baker J, Cottney JE, Houghton AK, McPhail P, Osprey A, Walker G, Adam JM. Moir EM, et al. Among authors: houghton ak. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7327-30. doi: 10.1016/j.bmcl.2010.10.061. Epub 2010 Oct 20. Bioorg Med Chem Lett. 2010. PMID: 21074434
Discovery of selective, orally bioavailable, N-linked arylsulfonamide Nav1.7 inhibitors with pain efficacy in mice.
Roecker AJ, Egbertson M, Jones KLG, Gomez R, Kraus RL, Li Y, Koser AJ, Urban MO, Klein R, Clements M, Panigel J, Daley C, Wang J, Finger EN, Majercak J, Santarelli V, Gregan I, Cato M, Filzen T, Jovanovska A, Wang YH, Wang D, Joyce LA, Sherer EC, Peng X, Wang X, Sun H, Coleman PJ, Houghton AK, Layton ME. Roecker AJ, et al. Among authors: houghton ak. Bioorg Med Chem Lett. 2017 May 15;27(10):2087-2093. doi: 10.1016/j.bmcl.2017.03.085. Epub 2017 Mar 30. Bioorg Med Chem Lett. 2017. PMID: 28389149
Benzoxazolinone aryl sulfonamides as potent, selective Nav1.7 inhibitors with in vivo efficacy in a preclinical pain model.
Pero JE, Rossi MA, Lehman HDGF, Kelly MJ 3rd, Mulhearn JJ, Wolkenberg SE, Cato MJ, Clements MK, Daley CJ, Filzen T, Finger EN, Gregan Y, Henze DA, Jovanovska A, Klein R, Kraus RL, Li Y, Liang A, Majercak JM, Panigel J, Urban MO, Wang J, Wang YH, Houghton AK, Layton ME. Pero JE, et al. Among authors: houghton ak. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2683-2688. doi: 10.1016/j.bmcl.2017.04.040. Epub 2017 Apr 22. Bioorg Med Chem Lett. 2017. PMID: 28465103
42 results