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Transcriptional profiling of the dose response: a more powerful approach for characterizing drug activities.
Ji RR, de Silva H, Jin Y, Bruccoleri RE, Cao J, He A, Huang W, Kayne PS, Neuhaus IM, Ott KH, Penhallow B, Cockett MI, Neubauer MG, Siemers NO, Ross-Macdonald P. Ji RR, et al. Among authors: siemers no. PLoS Comput Biol. 2009 Sep;5(9):e1000512. doi: 10.1371/journal.pcbi.1000512. Epub 2009 Sep 18. PLoS Comput Biol. 2009. PMID: 19763178 Free PMC article.
A high-resolution association mapping panel for the dissection of complex traits in mice.
Bennett BJ, Farber CR, Orozco L, Kang HM, Ghazalpour A, Siemers N, Neubauer M, Neuhaus I, Yordanova R, Guan B, Truong A, Yang WP, He A, Kayne P, Gargalovic P, Kirchgessner T, Pan C, Castellani LW, Kostem E, Furlotte N, Drake TA, Eskin E, Lusis AJ. Bennett BJ, et al. Genome Res. 2010 Feb;20(2):281-90. doi: 10.1101/gr.099234.109. Epub 2010 Jan 6. Genome Res. 2010. PMID: 20054062 Free PMC article.
SDRS--an algorithm for analyzing large-scale dose-response data.
Ji RR, Siemers NO, Lei M, Schweizer L, Bruccoleri RE. Ji RR, et al. Among authors: siemers no. Bioinformatics. 2011 Oct 15;27(20):2921-3. doi: 10.1093/bioinformatics/btr489. Epub 2011 Aug 24. Bioinformatics. 2011. PMID: 21865301 Free PMC article.
Biochemical and transcriptional profiling to triage additional activities in a series of IGF-1R/IR inhibitors.
Ross-Macdonald P, de Silva H, Patel V, Truong A, He A, Neuhaus I, Tilford C, Ji R, Siemers N, Greer A, Carboni J, Gottardis M, Menard K, Lee F, Dodier M, Frennesson D, Sampognaro A, Saulnier M, Trainor G, Vyas D, Zimmermann K, Wittman M. Ross-Macdonald P, et al. Bioorg Med Chem. 2012 Mar 15;20(6):1961-72. doi: 10.1016/j.bmc.2011.10.090. Epub 2011 Nov 6. Bioorg Med Chem. 2012. PMID: 22137930
An immune-active tumor microenvironment favors clinical response to ipilimumab.
Ji RR, Chasalow SD, Wang L, Hamid O, Schmidt H, Cogswell J, Alaparthy S, Berman D, Jure-Kunkel M, Siemers NO, Jackson JR, Shahabi V. Ji RR, et al. Among authors: siemers no. Cancer Immunol Immunother. 2012 Jul;61(7):1019-31. doi: 10.1007/s00262-011-1172-6. Epub 2011 Dec 7. Cancer Immunol Immunother. 2012. PMID: 22146893 Free PMC article. Clinical Trial.
Gene set enrichment analysis.
Tilford CA, Siemers NO. Tilford CA, et al. Among authors: siemers no. Methods Mol Biol. 2009;563:99-121. doi: 10.1007/978-1-60761-175-2_6. Methods Mol Biol. 2009. PMID: 19597782
26 results