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Potential scorpionate antibiotics: targeted hydrolysis of lipid II containing model membranes by vancomycin-TACzyme conjugates and modulation of their antibacterial activity by Zn-ions.
Bauke Albada H, Arnusch CJ, Branderhorst HM, Verel AM, Janssen WT, Breukink E, de Kruijff B, Pieters RJ, Liskamp RM. Bauke Albada H, et al. Among authors: breukink e. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3721-4. doi: 10.1016/j.bmcl.2009.05.064. Epub 2009 May 24. Bioorg Med Chem Lett. 2009. PMID: 19524434
The C terminus of SecA is involved in both lipid binding and SecB binding.
Breukink E, Nouwen N, van Raalte A, Mizushima S, Tommassen J, de Kruijff B. Breukink E, et al. J Biol Chem. 1995 Apr 7;270(14):7902-7. doi: 10.1074/jbc.270.14.7902. J Biol Chem. 1995. PMID: 7713885 Free article.
Using C-terminal deletion mutations in secA, we localized the previously proposed (Breukink, E., Keller, R.C. A., and de Kruijff, B. (1993), FEBS Lett. 331, 19-24) second lipid binding site on SecA. ...
Using C-terminal deletion mutations in secA, we localized the previously proposed (Breukink, E., Keller, R.C. A., and de Kruij …
156 results