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Hypoxia-mediated retinal neovascularization and vascular leakage in diabetic retina is suppressed by HIF-1α destabilization by SH-1242 and SH-1280, novel hsp90 inhibitors.
Jo DH, An H, Chang DJ, Baek YY, Cho CS, Jun HO, Park SJ, Kim JH, Lee HY, Kim KW, Lee J, Park HJ, Kim YM, Suh YG, Kim JH. Jo DH, et al. Among authors: kim ym, kim kw, kim jh. J Mol Med (Berl). 2014 Oct;92(10):1083-92. doi: 10.1007/s00109-014-1168-8. Epub 2014 May 31. J Mol Med (Berl). 2014. PMID: 24875598
Deguelin Analogue SH-1242 Inhibits Hsp90 Activity and Exerts Potent Anticancer Efficacy with Limited Neurotoxicity.
Lee SC, Min HY, Choi H, Bae SY, Park KH, Hyun SY, Lee HJ, Moon J, Park SH, Kim JY, An H, Park SJ, Seo JH, Lee S, Kim YM, Park HJ, Lee SK, Lee J, Lee J, Kim KW, Suh YG, Lee HY. Lee SC, et al. Among authors: kim jy, kim ym, kim kw. Cancer Res. 2016 Feb 1;76(3):686-99. doi: 10.1158/0008-5472.CAN-15-1492. Epub 2015 Dec 8. Cancer Res. 2016. PMID: 26645561
3,993 results