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A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice.
Enard W, Gehre S, Hammerschmidt K, Hölter SM, Blass T, Somel M, Brückner MK, Schreiweis C, Winter C, Sohr R, Becker L, Wiebe V, Nickel B, Giger T, Müller U, Groszer M, Adler T, Aguilar A, Bolle I, Calzada-Wack J, Dalke C, Ehrhardt N, Favor J, Fuchs H, Gailus-Durner V, Hans W, Hölzlwimmer G, Javaheri A, Kalaydjiev S, Kallnik M, Kling E, Kunder S, Mossbrugger I, Naton B, Racz I, Rathkolb B, Rozman J, Schrewe A, Busch DH, Graw J, Ivandic B, Klingenspor M, Klopstock T, Ollert M, Quintanilla-Martinez L, Schulz H, Wolf E, Wurst W, Zimmer A, Fisher SE, Morgenstern R, Arendt T, de Angelis MH, Fischer J, Schwarz J, Pääbo S. Enard W, et al. Among authors: gehre s. Cell. 2009 May 29;137(5):961-71. doi: 10.1016/j.cell.2009.03.041. Cell. 2009. PMID: 19490899 Free article.
A recent evolutionary change affects a regulatory element in the human FOXP2 gene.
Maricic T, Günther V, Georgiev O, Gehre S, Curlin M, Schreiweis C, Naumann R, Burbano HA, Meyer M, Lalueza-Fox C, de la Rasilla M, Rosas A, Gajovic S, Kelso J, Enard W, Schaffner W, Pääbo S. Maricic T, et al. Among authors: gehre s. Mol Biol Evol. 2013 Apr;30(4):844-52. doi: 10.1093/molbev/mss271. Epub 2012 Nov 28. Mol Biol Evol. 2013. PMID: 23197593
Radiotherapy combined with docetaxel alters the immune phenotype of HNSCC cells and results in increased surface expression of CD137 and release of HMGB1 of specifically HPV-positive tumor cells.
Grottker F, Gehre S, Reichardt CM, Sengedorj A, Jost T, Rieckmann T, Hecht M, Gostian AO, Frey B, Fietkau R, Gaipl US, Rückert M. Grottker F, et al. Among authors: gehre s. Neoplasia. 2023 Nov;45:100944. doi: 10.1016/j.neo.2023.100944. Epub 2023 Oct 17. Neoplasia. 2023. PMID: 37857049 Free PMC article.
Clonogenicity-based radioresistance determines the expression of immune suppressive immune checkpoint molecules after hypofractionated irradiation of MDA-MB-231 triple-negative breast cancer cells.
Gehre S, Meyer F, Sengedorj A, Grottker F, Reichardt CM, Alomo J, Borgmann K, Frey B, Fietkau R, Rückert M, Gaipl US. Gehre S, et al. Front Oncol. 2023 Apr 20;13:981239. doi: 10.3389/fonc.2023.981239. eCollection 2023. Front Oncol. 2023. PMID: 37152024 Free PMC article.