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Bicyclic cyanothiazolidines as novel dipeptidyl peptidase 4 inhibitors.
Betancort JM, Winn DT, Liu R, Xu Q, Liu J, Liao W, Chen SH, Carney D, Hanway D, Schmeits J, Li X, Gordon E, Campbell DA. Betancort JM, et al. Among authors: winn dt. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4437-40. doi: 10.1016/j.bmcl.2009.05.048. Epub 2009 May 18. Bioorg Med Chem Lett. 2009. PMID: 19482472
Synthesis and antiviral activity of HCV NS3/4A peptidomimetic boronic acid inhibitors.
Boloor A, Hanway D, Joshi M, Winn DT, Mendez G, Walls M, Wei P, Qian F, Zhang X, Zhang Y, Hepperle ME, Li X, Campbell DA, Betancort JM. Boloor A, et al. Among authors: winn dt. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5708-11. doi: 10.1016/j.bmcl.2009.08.017. Epub 2009 Aug 8. Bioorg Med Chem Lett. 2009. PMID: 19713109
First-in-class pan caspase inhibitor developed for the treatment of liver disease.
Linton SD, Aja T, Armstrong RA, Bai X, Chen LS, Chen N, Ching B, Contreras P, Diaz JL, Fisher CD, Fritz LC, Gladstone P, Groessl T, Gu X, Herrmann J, Hirakawa BP, Hoglen NC, Jahangiri KG, Kalish VJ, Karanewsky DS, Kodandapani L, Krebs J, McQuiston J, Meduna SP, Nalley K, Robinson ED, Sayers RO, Sebring K, Spada AP, Ternansky RJ, Tomaselli KJ, Ullman BR, Valentino KL, Weeks S, Winn D, Wu JC, Yeo P, Zhang CZ. Linton SD, et al. J Med Chem. 2005 Nov 3;48(22):6779-82. doi: 10.1021/jm050307e. J Med Chem. 2005. PMID: 16250635
High-resolution functional proteomics by active-site peptide profiling.
Okerberg ES, Wu J, Zhang B, Samii B, Blackford K, Winn DT, Shreder KR, Burbaum JJ, Patricelli MP. Okerberg ES, et al. Among authors: winn dt. Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):4996-5001. doi: 10.1073/pnas.0501205102. Epub 2005 Mar 28. Proc Natl Acad Sci U S A. 2005. PMID: 15795380 Free PMC article.
12 results