Site-directed mutagenesis of mouse dihydrofolate reductase. Mutants with increased resistance to methotrexate and trimethoprim.
Thillet J, Absil J, Stone SR, Pictet R.
Thillet J, et al. Among authors: pictet r.
J Biol Chem. 1988 Sep 5;263(25):12500-8.
J Biol Chem. 1988.
PMID: 3045118
Free article.
., Ribadeau-Dumas, B., Mousseron, S., Hung, A., Jami, J., and Pictet, R. (1984) Nucleic Acids Res. 12, 3585-3601). The choice of the mutated positions was based on the knowledge of the active site of chicken dihydrofolate reductase established by x-ray crystallograp …
., Ribadeau-Dumas, B., Mousseron, S., Hung, A., Jami, J., and Pictet, R. (1984) Nucleic Acids Res. 12, 3585-3601). The choice …