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Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.
Ahn K, Johnson DS, Mileni M, Beidler D, Long JZ, McKinney MK, Weerapana E, Sadagopan N, Liimatta M, Smith SE, Lazerwith S, Stiff C, Kamtekar S, Bhattacharya K, Zhang Y, Swaney S, Van Becelaere K, Stevens RC, Cravatt BF. Ahn K, et al. Among authors: zhang y. Chem Biol. 2009 Apr 24;16(4):411-20. doi: 10.1016/j.chembiol.2009.02.013. Chem Biol. 2009. PMID: 19389627 Free PMC article.
Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain.
Ahn K, Smith SE, Liimatta MB, Beidler D, Sadagopan N, Dudley DT, Young T, Wren P, Zhang Y, Swaney S, Van Becelaere K, Blankman JL, Nomura DK, Bhattachar SN, Stiff C, Nomanbhoy TK, Weerapana E, Johnson DS, Cravatt BF. Ahn K, et al. Among authors: zhang y. J Pharmacol Exp Ther. 2011 Jul;338(1):114-24. doi: 10.1124/jpet.111.180257. Epub 2011 Apr 19. J Pharmacol Exp Ther. 2011. PMID: 21505060 Free PMC article.
Development and validation of an LC-MS/MS method for quantification of cyclic guanosine 3',5'-monophosphate (cGMP) in clinical applications: a comparison with a EIA method.
Zhang Y, Dufield D, Klover J, Li W, Szekely-Klepser G, Lepsy C, Sadagopan N. Zhang Y, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Feb 15;877(5-6):513-20. doi: 10.1016/j.jchromb.2008.12.063. Epub 2009 Jan 6. J Chromatogr B Analyt Technol Biomed Life Sci. 2009. PMID: 19179124
Development and validation of a sample stabilization strategy and a UPLC-MS/MS method for the simultaneous quantitation of acetylcholine (ACh), histamine (HA), and its metabolites in rat cerebrospinal fluid (CSF).
Zhang Y, Tingley FD 3rd, Tseng E, Tella M, Yang X, Groeber E, Liu J, Li W, Schmidt CJ, Steenwyk R. Zhang Y, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Jul 15;879(22):2023-33. doi: 10.1016/j.jchromb.2011.05.030. Epub 2011 May 27. J Chromatogr B Analyt Technol Biomed Life Sci. 2011. PMID: 21684223
Characterization of cytochrome P450-mediated bioactivation of a compound containing the chemical scaffold, 4,5-dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide), to a chemically reactive p-chlorophenyl isocyanate intermediate in human liver microsomes.
Chen H, Zientek M, Jalaie M, Zhang Y, Bigge C, Mutlib A. Chen H, et al. Among authors: zhang y. Chem Res Toxicol. 2009 Sep;22(9):1603-12. doi: 10.1021/tx900167y. Chem Res Toxicol. 2009. PMID: 19697924
240,538 results
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