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A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis.
Ungaro R, Fukata M, Hsu D, Hernandez Y, Breglio K, Chen A, Xu R, Sotolongo J, Espana C, Zaias J, Elson G, Mayer L, Kosco-Vilbois M, Abreu MT. Ungaro R, et al. Among authors: chen a. Am J Physiol Gastrointest Liver Physiol. 2009 Jun;296(6):G1167-79. doi: 10.1152/ajpgi.90496.2008. Epub 2009 Apr 9. Am J Physiol Gastrointest Liver Physiol. 2009. PMID: 19359427 Free PMC article.
Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors.
Fukata M, Chen A, Vamadevan AS, Cohen J, Breglio K, Krishnareddy S, Hsu D, Xu R, Harpaz N, Dannenberg AJ, Subbaramaiah K, Cooper HS, Itzkowitz SH, Abreu MT. Fukata M, et al. Among authors: chen a. Gastroenterology. 2007 Dec;133(6):1869-81. doi: 10.1053/j.gastro.2007.09.008. Epub 2007 Sep 14. Gastroenterology. 2007. PMID: 18054559 Free PMC article.
Farnesoid X receptor expression is decreased in colonic mucosa of patients with primary sclerosing cholangitis and colitis-associated neoplasia.
Torres J, Bao X, Iuga AC, Chen A, Harpaz N, Ullman T, Cohen BL, Pineton de Chambrun G, Asciutti S, Odin JA, Sachar DB, Gaskins HR, Setchell K, Colombel JF, Itzkowitz SH. Torres J, et al. Among authors: chen a. Inflamm Bowel Dis. 2013 Feb;19(2):275-82. doi: 10.1097/MIB.0b013e318286ff2e. Inflamm Bowel Dis. 2013. PMID: 23348121
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