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High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus.
Drew BG, Duffy SJ, Formosa MF, Natoli AK, Henstridge DC, Penfold SA, Thomas WG, Mukhamedova N, de Courten B, Forbes JM, Yap FY, Kaye DM, van Hall G, Febbraio MA, Kemp BE, Sviridov D, Steinberg GR, Kingwell BA. Drew BG, et al. Among authors: yap fy. Circulation. 2009 Apr 21;119(15):2103-11. doi: 10.1161/CIRCULATIONAHA.108.843219. Epub 2009 Apr 6. Circulation. 2009. PMID: 19349317 Clinical Trial.
Advanced glycation end products are direct modulators of β-cell function.
Coughlan MT, Yap FY, Tong DC, Andrikopoulos S, Gasser A, Thallas-Bonke V, Webster DE, Miyazaki J, Kay TW, Slattery RM, Kaye DM, Drew BG, Kingwell BA, Fourlanos S, Groop PH, Harrison LC, Knip M, Forbes JM. Coughlan MT, et al. Among authors: yap fy. Diabetes. 2011 Oct;60(10):2523-32. doi: 10.2337/db10-1033. Epub 2011 Sep 12. Diabetes. 2011. PMID: 21911745 Free PMC article.
Increased liver AGEs induce hepatic injury mediated through an OST48 pathway.
Zhuang A, Yap FY, Bruce C, Leung C, Plan MR, Sullivan MA, Herath C, McCarthy D, Sourris KC, Kantharidis P, Coughlan MT, Febbraio MA, Hodson MP, Watt MJ, Angus P, Schulz BL, Forbes JM. Zhuang A, et al. Among authors: yap fy. Sci Rep. 2017 Sep 25;7(1):12292. doi: 10.1038/s41598-017-12548-4. Sci Rep. 2017. PMID: 28947796 Free PMC article.
The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition).
Zhuang A, Yap FYT, Borg DJ, McCarthy D, Fotheringham A, Leung S, Penfold SA, Sourris KC, Coughlan MT, Schulz BL, Forbes JM. Zhuang A, et al. Among authors: yap fyt. Endocrinol Diabetes Metab. 2021 Jun 22;4(3):e00278. doi: 10.1002/edm2.278. eCollection 2021 Jul. Endocrinol Diabetes Metab. 2021. PMID: 34277994 Free PMC article.
32 results