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Functional recovery after delayed treatment of ischemic stroke with melanocortins is associated with overexpression of the activity-dependent gene Zif268.
Giuliani D, Ottani A, Minutoli L, Stefano VD, Galantucci M, Bitto A, Zaffe D, Altavilla D, Botticelli AR, Squadrito F, Guarini S. Giuliani D, et al. Among authors: botticelli ar. Brain Behav Immun. 2009 Aug;23(6):844-50. doi: 10.1016/j.bbi.2009.03.009. Epub 2009 Apr 5. Brain Behav Immun. 2009. PMID: 19345727
Both early and delayed treatment with melanocortin 4 receptor-stimulating melanocortins produces neuroprotection in cerebral ischemia.
Giuliani D, Mioni C, Altavilla D, Leone S, Bazzani C, Minutoli L, Bitto A, Cainazzo MM, Marini H, Zaffe D, Botticelli AR, Pizzala R, Savio M, Necchi D, Schiöth HB, Bertolini A, Squadrito F, Guarini S. Giuliani D, et al. Among authors: botticelli ar. Endocrinology. 2006 Mar;147(3):1126-35. doi: 10.1210/en.2005-0692. Epub 2005 Oct 27. Endocrinology. 2006. PMID: 16254026
Broad therapeutic treatment window of [Nle(4), D-Phe(7)]alpha-melanocyte-stimulating hormone for long-lasting protection against ischemic stroke, in Mongolian gerbils.
Giuliani D, Leone S, Mioni C, Bazzani C, Zaffe D, Botticelli AR, Altavilla D, Galantucci M, Minutoli L, Bitto A, Squadrito F, Guarini S. Giuliani D, et al. Among authors: botticelli ar. Eur J Pharmacol. 2006 May 24;538(1-3):48-56. doi: 10.1016/j.ejphar.2006.03.038. Epub 2006 Mar 24. Eur J Pharmacol. 2006. PMID: 16647700
Treatment of cerebral ischemia with melanocortins acting at MC4 receptors induces marked neurogenesis and long-lasting functional recovery.
Giuliani D, Zaffe D, Ottani A, Spaccapelo L, Galantucci M, Minutoli L, Bitto A, Irrera N, Contri M, Altavilla D, Botticelli AR, Squadrito F, Guarini S. Giuliani D, et al. Among authors: botticelli ar. Acta Neuropathol. 2011 Oct;122(4):443-53. doi: 10.1007/s00401-011-0873-4. Epub 2011 Sep 17. Acta Neuropathol. 2011. PMID: 21927944
Melanocortins protect against progression of Alzheimer's disease in triple-transgenic mice by targeting multiple pathophysiological pathways.
Giuliani D, Bitto A, Galantucci M, Zaffe D, Ottani A, Irrera N, Neri L, Cavallini GM, Altavilla D, Botticelli AR, Squadrito F, Guarini S. Giuliani D, et al. Among authors: botticelli ar. Neurobiol Aging. 2014 Mar;35(3):537-47. doi: 10.1016/j.neurobiolaging.2013.08.030. Epub 2013 Oct 1. Neurobiol Aging. 2014. PMID: 24094579
Activation of an efferent cholinergic pathway produces strong protection against myocardial ischemia/reperfusion injury in rats.
Mioni C, Bazzani C, Giuliani D, Altavilla D, Leone S, Ferrari A, Minutoli L, Bitto A, Marini H, Zaffe D, Botticelli AR, Iannone A, Tomasi A, Bigiani A, Bertolini A, Squadrito F, Guarini S. Mioni C, et al. Among authors: botticelli ar. Crit Care Med. 2005 Nov;33(11):2621-8. doi: 10.1097/01.ccm.0000186762.05301.13. Crit Care Med. 2005. PMID: 16276189
Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage.
Giuliani D, Mioni C, Bazzani C, Zaffe D, Botticelli AR, Capolongo S, Sabba A, Galantucci M, Iannone A, Grieco P, Novellino E, Colombo G, Tomasi A, Catania A, Guarini S. Giuliani D, et al. Among authors: botticelli ar. Br J Pharmacol. 2007 Mar;150(5):595-603. doi: 10.1038/sj.bjp.0707115. Epub 2007 Jan 22. Br J Pharmacol. 2007. PMID: 17245369 Free PMC article.
113 results